Web-Based Ovarian Cancer Symptom Control: Nurse-Guided vs. Self-Directed

基于网络的卵巢癌症状控制:护士指导与自我指导

基本信息

  • 批准号:
    7580137
  • 负责人:
  • 金额:
    $ 57.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-29 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Over 22,000 women will be diagnosed with ovarian cancer in 2008. Most will be diagnosed in advanced stages, and will experience a recurrence within 2 years after treatment. Aggressive chemotherapy and disease progression cause a wide range of symptoms that can significantly impair quality of life (QOL). An innovative intervention, WRITE Symptoms(c) [Written Representational Intervention To Ease Symptoms], builds on previous approaches to symptom management through an emphasis on understanding a patient's representation of her most significant symptom cluster prior to providing new information. Currently, WRITE Symptoms(c) is delivered by nurses via Internet message boards. A current pilot study of women with recurrent ovarian cancer has shown that WRITE Symptoms(c) is a feasible, acceptable intervention, and preliminary analyses provide early support for efficacy of the intervention. A key question is whether individualization by nurses is critical to the success of the WRITE Symptoms(c) Intervention, or whether women can be guided through the program by a web-based, interactive computer module without assistance from a nurse (referred to as "Self-directed WRITE Symptoms(c)"). Development of the self- directed module is complete and preliminary evaluations support its feasibility; acceptability; and content, functional, and theoretical validity. The primary aim of the proposed study is to compare the efficacy of nurse-guided WRITE Symptoms(c) vs. self-directed WRITE Symptoms(c) vs. care as usual in improving representations (severity, consequences, distress, and controllability) of target symptoms for women with recurrent ovarian cancer. Secondary aims are to 1) compare the relative efficacy of each intervention for improving QOL, communication with health care providers, and use of symptom management strategies; 2) explore potential long-term effects of the 3) evaluate whether changes in symptom representations mediate changes in QOL; and 4) evaluate moderators of intervention effect. To address study aims, 480 women with recurrent ovarian cancer who are experiencing 3 or more disease- or treatment-related symptoms will be recruited from Gynecologic Oncology Group clinics across the country. Subjects will complete baseline measures of demographic and clinical information, symptom representations, and QOL. Following baseline assessment, women will be randomly assigned to one of three interventions: nurse-guided WRITE Symptoms(c), self- directed WRITE Symptoms(c), or Care-as-usual. Subjects in the two WRITE Symptoms arms engage in the interventions over the first 7 weeks of the study. Outcome measures are assessed monthly. This study evaluates an innovative approach to symptom assessment and management. The knowledge to be gained about critical components of psycho-educational interventions and mechanisms through which they effect changes in outcomes could improve symptom management across patient populations. interventions; PUBLIC HEALTH RELEVANCE: Each year over 22,000 women are diagnosed with ovarian cancer and over 14,000 die of the disease. Research to improve the quality of life for ovarian cancer patients was identified as a priority at the 2000 CDC sponsored workshop entitled "Identifying Public Health Opportunities to Reduce the Burden of Ovarian Cancer". Information gained from the proposed study testing the efficacy of two web-based approaches to ovarian cancer symptom management should advance understanding of the critical elements of interventions needed to reduce cancer-related morbidity in improve quality of life.
描述(申请人提供): 2008 年将有超过 22,000 名女性被诊断出患有卵巢癌。大多数人在诊断时已处于晚期,并且会在治疗后 2 年内复发。积极的化疗和疾病进展会导致多种症状,严重损害生活质量 (QOL)。 WRITE Symptoms(c) [缓解症状的书面代表性干预措施] 是一种创新干预措施,它建立在以前的症状管理方法的基础上,强调在提供新信息之前了解患者最重要症状群的表征。目前,“WRITE Symptoms(c)”是由护士通过互联网留言板发布的。目前一项针对复发性卵巢癌女性的试点研究表明,WRITE Symptoms(c) 是一种可行、可接受的干预措施,初步分析为干预措施的功效提供了早期支持。一个关键问题是护士的个性化是否对 WRITE Symptoms(c) 干预的成功至关重要,或者妇女是否可以在没有护士协助的情况下通过基于网络的交互式计算机模块指导妇女完成该计划(称为“自我指导的 WRITE Symptoms(c)”)。自主模块开发已完成,初步评估支持其可行性;可接受性;以及内容、功能和理论的有效性。拟议研究的主要目的是比较护士指导的 WRITE Symptoms(c) 与自我指导的 WRITE Symptoms(c) 与照常护理在改善复发性卵巢癌女性目标症状的表现(严重性、后果、痛苦和可控性)方面的效果。次要目标是 1) 比较每种干预措施在改善生活质量、与医疗保健提供者的沟通以及症状管理策略的使用方面的相对功效; 2) 探索 3) 评估症状表征的变化是否会介导 QOL 的变化的潜在长期影响; 4)评估干预效果的调节因素。为了实现研究目标,将从全国各地的妇科肿瘤小组诊所招募 480 名患有复发性卵巢癌且患有 3 种或以上疾病或治疗相关症状的女性。受试者将完成人口统计和临床信息、症状表征和生活质量的基线测量。基线评估后,女性将被随机分配接受三种干预措施之一:护士指导的 WRITE 症状 (c)、自我指导的 WRITE 症状 (c) 或照常护理。两个 WRITE Symptoms 组的受试者在研究的前 7 周内进行干预。结果衡量指标每月进行一次评估。这项研究评估了症状评估和管理的创新方法。获得有关心理教育干预措施的关键组成部分及其影响结果变化的机制的知识可以改善患者群体的症状管理。干预措施;公共卫生相关性:每年有超过 22,000 名女性被诊断患有卵巢癌,超过 14,000 人死于该病。 2000 年 CDC 主办的题为“确定减轻卵巢癌负担的公共卫生机会”的研讨会将改善卵巢癌患者生活质量的研究确定为优先事项。从拟议的研究中获得的信息测试了两种基于网络的卵巢癌症状管理方法的功效,这应该可以促进人们对减少癌症相关发病率、提高生活质量所需的干预措施的关键要素的理解。

项目成果

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Heidi S Donovan其他文献

Heidi S Donovan的其他文献

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{{ truncateString('Heidi S Donovan', 18)}}的其他基金

SmartCare: Innovations in Caregiving Interventions
SmartCare:护理干预的创新
  • 批准号:
    9081264
  • 财政年份:
    2012
  • 资助金额:
    $ 57.93万
  • 项目类别:
SmartCare: Innovations in Caregiving Interventions
SmartCare:护理干预的创新
  • 批准号:
    8218490
  • 财政年份:
    2012
  • 资助金额:
    $ 57.93万
  • 项目类别:
SmartCare: Innovations in Caregiving Interventions
SmartCare:护理干预的创新
  • 批准号:
    8551701
  • 财政年份:
    2012
  • 资助金额:
    $ 57.93万
  • 项目类别:
SmartCare: Innovations in Caregiving Interventions
SmartCare:护理干预的创新
  • 批准号:
    8680052
  • 财政年份:
    2012
  • 资助金额:
    $ 57.93万
  • 项目类别:
SmartCare: Innovations in Caregiving Interventions
SmartCare:护理干预的创新
  • 批准号:
    8889080
  • 财政年份:
    2012
  • 资助金额:
    $ 57.93万
  • 项目类别:
Web-Based Ovarian Cancer Symptom Control: Nurse-Guided vs. Self-Directed
基于网络的卵巢癌症状控制:护士指导与自我指导
  • 批准号:
    8091234
  • 财政年份:
    2008
  • 资助金额:
    $ 57.93万
  • 项目类别:
Web-Based Ovarian Cancer Symptom Control: Nurse-Guided vs. Self-Directed
基于网络的卵巢癌症状控制:护士指导与自我指导
  • 批准号:
    7890458
  • 财政年份:
    2008
  • 资助金额:
    $ 57.93万
  • 项目类别:
Web-Based Ovarian Cancer Symptom Control: Nurse-Guided vs. Self-Directed
基于网络的卵巢癌症状控制:护士指导与自我指导
  • 批准号:
    8282641
  • 财政年份:
    2008
  • 资助金额:
    $ 57.93万
  • 项目类别:
Web-Based Ovarian Cancer Symptom Control: Nurse-Guided vs. Self-Directed
基于网络的卵巢癌症状控制:护士指导与自我指导
  • 批准号:
    7694379
  • 财政年份:
    2008
  • 资助金额:
    $ 57.93万
  • 项目类别:
Internet-Based Cancer Symptom Management: WRITE Symptoms
基于互联网的癌症症状管理:WRITE Symptoms
  • 批准号:
    6967219
  • 财政年份:
    2005
  • 资助金额:
    $ 57.93万
  • 项目类别:

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