Cross-talk between ganglion-cell photoreceptors and other neurons in the retina

神经节细胞感光器和视网膜其他神经元之间的串扰

基本信息

  • 批准号:
    7625897
  • 负责人:
  • 金额:
    $ 8.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-06-01 至 2009-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): One function of the visual system is to enable conscious visual perception of details in the environment; this requires the rod and cone photoreceptor cells in the retina. The visual system also mediates subconscious photic regulation of various physiological functions such as resetting of our body clocks to the solar cycle. Failure to reset these clocks results in "jet lag" symptoms which can have serious health consequences including sleep disorders and cancer. Subconscious photoreception requires not only rods and cones but also the recently discovered ganglion-cell photoreceptors, i.e. the intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs interact bidirectionally with rod/cone-driven bipolar-cell and amacrine-cell circuits. This proposal uses electrophysiological and imaging methods to study such interactions in rodent retinas and comprises three goals: (1) To characterize the functions and morphologies of bipolar and amacrine cells innervating the ipRGCs, through dual intracellular recordings from a bipolar/amacrine cell and an ipRGC followed by fluorescence imaging of dyes injected into these cells; (2) To examine the influence of dopamine and other amacrine-cell neuromodulators on ipRGC light responses by analyzing the effects of receptor agonists and antagonists; and (3) To investigate which bipolar and amacrine cell types receive synaptic inputs from ipRGCs, through dual intracellular recordings followed by fluorescence imaging. Findings from these studies will enable a better understanding of how rod/cone signals regulate our body clocks, and will also provide clues as to how the ipRGCs may modulate rod/cone circuits and thus conscious visual perception. LAY SUMMARY: Neuronal circuits for conscious vision and for subconscious visual functions (e.g. regulation of sleep timing) interact in the retina. This proposal will study the functional roles of such interactions and may help design better therapies and workplace policies combating or preventing jet lag problems. CANDIDATE: My #1 career goal is to get a faculty position and continue to explore neuronal mechanisms for both conscious and subconscious vision. This K99/R00 award will help me achieve this goal, since I will learn imaging and anatomical techniques from my sponsor, and the award topic is highly relevant to my long-term research interests and will be a basis for future ROVs. The excellent research facilities and mentor support at Brown University will greatly facilitate execution of the planned experiments.
描述(由申请人提供):视觉系统的功能之一是能够对环境中的细节进行有意识的视觉感知;这需要视网膜上的视杆细胞和视锥细胞。视觉系统还可以调节各种生理功能的潜意识光调节,例如将我们的生物钟重置为太阳周期。不能重置这些生物钟会导致“时差”症状,这可能会对健康造成严重后果,包括睡眠障碍和癌症。潜意识的光接受不仅需要视杆细胞和视锥细胞,还需要最近发现的神经节细胞光感受器,即固有光敏视网膜神经节细胞(ipRGCs)。iprgc与杆状/锥体驱动的双极细胞和无腺细胞电路双向相互作用。本研究利用电生理学和成像方法研究啮齿动物视网膜中的这种相互作用,包括三个目标:(1)通过双极/无突细胞和ipRGC的双胞内记录,以及注射到这些细胞中的染料的荧光成像,表征支配ipRGC的双极和无突细胞的功能和形态;(2)通过分析受体激动剂和拮抗剂的作用,探讨多巴胺和其他无分泌细胞神经调节剂对ipRGC光反应的影响;(3)通过双胞内记录和荧光成像,研究哪一种双极性和无分泌细胞类型接受iprgc的突触输入。这些研究的发现将有助于更好地理解视杆/视锥细胞信号如何调节我们的生物钟,也将为ipRGCs如何调节视杆/视锥细胞回路从而实现有意识的视觉感知提供线索。摘要:有意识视觉和潜意识视觉功能(如调节睡眠时间)的神经回路在视网膜中相互作用。该提案将研究这种相互作用的功能角色,并可能有助于设计更好的治疗方法和工作场所政策,以对抗或预防时差问题。候选人:我的第一职业目标是获得教职,并继续探索意识和潜意识视觉的神经元机制。这个K99/R00奖项将帮助我实现这一目标,因为我将从我的赞助商那里学习成像和解剖技术,并且这个奖项的主题与我的长期研究兴趣高度相关,将成为未来rov的基础。布朗大学优秀的研究设施和导师的支持将极大地促进计划实验的实施。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Circadian modulation of melanopsin-driven light response in rat ganglion-cell photoreceptors.
  • DOI:
    10.1177/0748730409343767
  • 发表时间:
    2009-10
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Weng S;Wong KY;Berson DM
  • 通讯作者:
    Berson DM
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KWOON Y. WONG其他文献

KWOON Y. WONG的其他文献

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{{ truncateString('KWOON Y. WONG', 18)}}的其他基金

Physiology of intrinsically photosensitive retinal ganglion cells
本质光敏视网膜神经节细胞的生理学
  • 批准号:
    8698759
  • 财政年份:
    2013
  • 资助金额:
    $ 8.42万
  • 项目类别:
Retrograde Signaling by Intrinsically Photosensitive Retinal Ganglion Cells
本质光敏视网膜神经节细胞的逆行信号传导
  • 批准号:
    9885119
  • 财政年份:
    2013
  • 资助金额:
    $ 8.42万
  • 项目类别:
Physiology of intrinsically photosensitive retinal ganglion cells
本质光敏视网膜神经节细胞的生理学
  • 批准号:
    9095318
  • 财政年份:
    2013
  • 资助金额:
    $ 8.42万
  • 项目类别:
Physiology of intrinsically photosensitive retinal ganglion cells
本质光敏视网膜神经节细胞的生理学
  • 批准号:
    8560727
  • 财政年份:
    2013
  • 资助金额:
    $ 8.42万
  • 项目类别:
Cross-talk between ganglion-cell photoreceptors and other neurons in the retina
神经节细胞感光器和视网膜其他神经元之间的串扰
  • 批准号:
    8240495
  • 财政年份:
    2008
  • 资助金额:
    $ 8.42万
  • 项目类别:
Cross-talk between ganglion-cell photoreceptors and other neurons in the retina
神经节细胞感光器和视网膜其他神经元之间的串扰
  • 批准号:
    8053770
  • 财政年份:
    2008
  • 资助金额:
    $ 8.42万
  • 项目类别:
Cross-talk between ganglion-cell photoreceptors and other neurons in the retina
神经节细胞感光器和视网膜其他神经元之间的串扰
  • 批准号:
    7448174
  • 财政年份:
    2008
  • 资助金额:
    $ 8.42万
  • 项目类别:
Cross-talk between ganglion-cell photoreceptors and other neurons in the retina
神经节细胞感光器和视网膜其他神经元之间的串扰
  • 批准号:
    7978576
  • 财政年份:
    2008
  • 资助金额:
    $ 8.42万
  • 项目类别:
Retinal Inputs to the Mammalian Circadian Pacemaker
哺乳动物昼夜节律起搏器的视网膜输入
  • 批准号:
    7049350
  • 财政年份:
    2005
  • 资助金额:
    $ 8.42万
  • 项目类别:
Retinal Inputs to the Mammalian Circadian Pacemaker
哺乳动物昼夜节律起搏器的视网膜输入
  • 批准号:
    6938703
  • 财政年份:
    2005
  • 资助金额:
    $ 8.42万
  • 项目类别:

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