Patient Oriented Research in Pediatric Kidney Disease

描述（由申请人提供）： 博士Furth的长期职业目标是将定义肾脏疾病进展风险因素的流行病学研究方法与阐明儿童肾脏疾病进展机制的转化研究联系起来。本研究的目标是确定干预措施的生物靶点，以减缓肾病进展，降低发病率并改善受影响个体的健康相关生活质量。通过指导儿科肾脏病学、儿科泌尿学和相关学科的临床研究员和初级教师，Furth博士的目标是与约翰霍普金斯现有的T32、K12和K30培训项目合作，培养出优秀的临床科学家，他们将继续成为独立的研究人员。K24奖将有助于为她提供时间进行项目建设和指导。她希望在接下来的几年里继续投入时间和精力，通过将实验室科学的生物医学研究人员与临床研究人员和流行病学家聚集在一起，以更好地了解导致儿童肾脏疾病发展，进展和结局差异的因素，重点建立儿童肾脏疾病研究的跨学科计划。在儿童慢性肾脏病（CKiD）的前瞻性研究中，她是主要研究者，Furth博士和她的同事创建了一个标本库（血清，血浆和淋巴细胞系），可用于检查遗传多态性，炎症介质和其他生物标志物在肾脏疾病及其并发症进展中的作用。第二个相关的职业目标是加强霍普金斯的肾脏疾病研究培训计划。Furth博士希望继续促进肾脏病学和其他学科的学员的职业生涯，使他们成为肾脏疾病领域的创造性和独立的以患者为导向的研究人员，以加快从床边到实践的转变步伐。Furth博士的近期职业目标是：1）继续她在儿童慢性肾脏疾病方面的工作; 2）继续为初级临床研究人员提供出色的指导，开展严格的以患者为导向的儿科研究; 3）开发和测试新方法，以阐明肾脏疾病进展及其相关发病率的机制。

DESCRIPTION (provided by applicant): Dr. Furth's long-term career goal is to link epidemiologic research methods defining risk factors for kidney disease progression with translational studies elucidating mechanisms of kidney disease progression in children. The goal of this research trajectory is to define biologic targets for interventions to slow progression of kidney disease, decreasing morbidity and improving health related quality of life for affected individuals. Through her mentoring of clinical fellows and junior faculty in pediatric nephrology, pediatric urology and related disciplines, Dr. Furth' goal is to work with the existing T32, K12 and K30 training programs at Johns Hopkins to produce outstanding clinical scientists who go on to be independent investigators. The K24 award will be instrumental in providing her with time for program building and mentoring. She would like to devote continued time and effort over the next several years focused on building an interdisciplinary program in kidney disease research in children by bringing together biomedical researchers in the laboratory sciences with clinical researchers and epidemiologists to better understand the factors leading to disparities in the development, progression and outcome of kidney disease in children. In the prospective study of Chronic Kidney Disease in Children (CKiD) for which she is a Principal Investigator, Dr. Furth and her colleagues have created a specimen bank (serum, plasma and lymphocyte cell lines) that can be used to examine genetic polymorphisms, inflammatory mediators and the role of other biomarkers in the progression of kidney disease and its complications. A second and related career goal is to enhance the Kidney Disease Research Training Program at Hopkins. Dr. Furth would like to continue to catalyze the careers of trainees in nephrology and other disciplines to become creative and independent patient-oriented researchers in kidney disease to accelerate the pace of translation from bedside to practice. Dr. Furth's immediate career objectives are: 1) To continue her work in chronic kidney disease in children; 2) To continue to provide outstanding mentorship for junior clinician investigators in the conduct of rigorous patient-oriented pediatric research; and 3) To develop and test novel methods to elucidate mechanisms of kidney disease progression and it associated morbidities.