Patient Oriented Research in Pediatric Kidney Disease

描述(由申请人提供)： 弗思博士的长期职业目标是将确定肾脏疾病进展风险因素的流行病学研究方法与阐明儿童肾脏疾病进展机制的翻译研究联系起来。这项研究的目标是确定干预措施的生物学目标，以减缓肾脏疾病的进展，降低发病率，并改善受影响个人的健康相关生活质量。通过指导儿科肾病、儿科泌尿外科和相关学科的临床研究员和初级教员，Furth博士的目标是与约翰霍普金斯大学现有的T32、K12和K30培训计划合作，培养出优秀的临床科学家，他们后来成为独立的研究人员。K24奖将有助于为她提供项目建设和指导的时间。她希望在接下来的几年里继续投入时间和精力，通过将实验室科学中的生物医学研究人员与临床研究人员和流行病学家聚集在一起，更好地了解导致儿童肾脏疾病发展、进展和结果差异的因素，专注于建立儿童肾脏疾病研究的跨学科计划。在她担任首席研究员的儿童慢性肾脏疾病前瞻性研究(CKiD)中，Furth博士和她的同事创建了一个样本库(血清、血浆和淋巴细胞株)，可用于检测基因多态、炎症介质以及其他生物标记物在肾脏疾病及其并发症的进展中的作用。第二个相关的职业目标是加强霍普金斯大学的肾脏疾病研究培训计划。弗思博士希望继续促进肾脏病学和其他学科实习生的职业生涯，成为富有创造力和独立、以患者为中心的肾脏疾病研究人员，以加快从床边到实践的转变步伐。弗思博士目前的职业目标是：1)继续她在儿童慢性肾脏疾病方面的工作；2)继续为初级临床医生研究人员提供出色的指导，开展严格的以患者为中心的儿科研究；3)开发和测试新的方法，以阐明肾脏疾病进展及其相关疾病的机制。

DESCRIPTION (provided by applicant): Dr. Furth's long-term career goal is to link epidemiologic research methods defining risk factors for kidney disease progression with translational studies elucidating mechanisms of kidney disease progression in children. The goal of this research trajectory is to define biologic targets for interventions to slow progression of kidney disease, decreasing morbidity and improving health related quality of life for affected individuals. Through her mentoring of clinical fellows and junior faculty in pediatric nephrology, pediatric urology and related disciplines, Dr. Furth' goal is to work with the existing T32, K12 and K30 training programs at Johns Hopkins to produce outstanding clinical scientists who go on to be independent investigators. The K24 award will be instrumental in providing her with time for program building and mentoring. She would like to devote continued time and effort over the next several years focused on building an interdisciplinary program in kidney disease research in children by bringing together biomedical researchers in the laboratory sciences with clinical researchers and epidemiologists to better understand the factors leading to disparities in the development, progression and outcome of kidney disease in children. In the prospective study of Chronic Kidney Disease in Children (CKiD) for which she is a Principal Investigator, Dr. Furth and her colleagues have created a specimen bank (serum, plasma and lymphocyte cell lines) that can be used to examine genetic polymorphisms, inflammatory mediators and the role of other biomarkers in the progression of kidney disease and its complications. A second and related career goal is to enhance the Kidney Disease Research Training Program at Hopkins. Dr. Furth would like to continue to catalyze the careers of trainees in nephrology and other disciplines to become creative and independent patient-oriented researchers in kidney disease to accelerate the pace of translation from bedside to practice. Dr. Furth's immediate career objectives are: 1) To continue her work in chronic kidney disease in children; 2) To continue to provide outstanding mentorship for junior clinician investigators in the conduct of rigorous patient-oriented pediatric research; and 3) To develop and test novel methods to elucidate mechanisms of kidney disease progression and it associated morbidities.