The Genetics and Prevention of Gastrointestinal Cancers

描述（由申请人提供）：此K24应用程序有两个广泛的目标：指导初级研究人员在以患者为导向的研究和追求和扩大在遗传学和预防胃肠道癌症的研究计划。 候选人Sapna Syngal，医学博士，公共卫生硕士，是哈佛医学院的医学助理教授，在Dana-Farber癌症研究所的人口科学部和Brigham妇女医院的胃肠病学部有双重任命。 她在支持和促进从事以患者为导向的胃肠病学研究的医生的职业生涯方面建立了良好的记录。 她目前的学员包括14名博士后研究员，他们都是来自各种亚专业背景的医生，包括胃肠病学，遗传学，内科学和肿瘤学。 所有完成Syngal博士培训的学员在培训期间都获得了哈佛公共卫生学院的公共卫生硕士学位，目前在学术机构担任教职，将大部分时间用于开展以患者为导向的研究。 Syngal博士是各种NIH培训赠款的活跃教员，包括胃肠病学T32，遗传学T32和癌症结局R25-这些培训赠款为Syngal博士计划中的当前博士后研究员提供工资支持以及MPH学位的学费。 2003年，她被丹娜-法伯癌症研究所授予“弗雷德·P·李导师奖”。 博士Syngal的研究项目包括评估（1）结直肠癌高危患者的筛查依从性;（2）错配修复基因MSH 6在家族性结直肠癌中的作用;（3）遗传检测对遗传性结直肠癌监测和管理的影响;（4）MSH 2和MLH 1基因突变携带者的预测规则的开发;（5）遗传性结直肠癌的诊断。（5）粪便DMA试验和其他生物标志物用于结直肠癌早期检测的研究。 Syngal博士是K 07和RO 1奖的首席研究员，也是其他几个多中心NIH赠款的共同研究员。 Syngal博士于2004年获得美国胃肠病协会颁发的青年研究者临床科学奖，这是阿加每年向全国一名初级临床研究人员颁发的最高荣誉。

DESCRIPTION (provided by applicant): This K24 application has two broad goals: mentoring junior investigators in patient-oriented research and pursuing and expanding a research program in the genetics and prevention of gastrointestinal cancers. The candidate, Sapna Syngal, MD, MPH, is an Assistant Professor of Medicine at Harvard Medical School, with dual appointments in the Population Sciences Division of Dana-Farber Cancer Institute and the Gastroenterology Division at Brigham and Women's Hospital. She has established a track record at supporting and advancing the careers of physicians pursuing patient-oriented research in gastroenterology. Her current group of mentees include 14 post-doctoral fellows, all who are physicians from a variety of subspecialty backgrounds including gastroenterology, genetics, internal medicine and oncology. All mentees who have completed training with Dr. Syngal obtained a Masters in Public Health from the Harvard School of Public Health during their training period and currently hold faculty positions in academic institutions, devoting the majority of their time to pursuing patient-oriented research. Dr. Syngal is an active faculty member of a variety of NIH training grants, including a T32 in Gastroenterology, a T32 in Genetics and a R25 in Cancer Outcomes - these training grants provide salary support for the current post-doctoral fellows in Dr. Syngal's program as well as tuition costs for the MPH degree. She has been honored for mentoring by the Dana-Farber Cancer Institute Fred P Li Award for Mentoring in 2003. Dr. Syngal's research program includes evaluation of (1) screening compliance in patients at high risk for colorectal cancer; (2) the role of the mismatch repair gene, MSH6 in familial colorectal cancer; (3) the impact of genetic testing on surveillance and management of hereditary colon cancer; (4) the development of a prediction rule for mutation carriers in the MSH2 and MLH1 genes; and (5) the study of stool DMA tests and other biomarkers for early detection of colorectal cancer. Dr, Syngal is the Principal Investigator of a K07 and an RO1 award and a co-investigator on several other multi-center NIH grants. Dr. Syngal received the Young Investigator Clinical Science Award in 2004 by the American Gastroenterological Association, the, highest honor given by the AGA to one junior faculty clinical investigator nationally per year.