The Genetics and Prevention of Gastrointestinal Cancers

胃肠道癌症的遗传学和预防

• 批准号: 7663971
• 负责人: SAPNA SYNGAL
• 金额: $ 15.25万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7663971
• 关键词: Accounting; Affect; Age; American; Appointment; Area; Award; Biological Markers; Cancer Control; Cancer Family; Cancer-Predisposing Gene; Characteristics; Clinic; Clinical; Clinical Investigator; Clinical Sciences; Colon Carcinoma; Colorectal Cancer; Dana-Farber Cancer Institute; Data; Data Analyses; Development; Diagnosis; Employee Strikes; Enrollment; Evaluation; Faculty; Family; Family history of; Feces; Frequencies; Funding; Future; Gastroenterology; Genes; Genetic; Genetic Predisposition to Disease; Genetic screening method; Germ-Line Mutation; Goals; Grant; Hereditary Malignant Neoplasm; Hereditary Nonpolyposis Colorectal Neoplasms; Hospitals; Human; Industry; Inherited; Institution; Internal Medicine; MLH1 gene; MSH2 gene; MSH6 gene; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Manuscripts; Medical Records; Medicine; Mentors; Microsatellite Instability; Mismatch Repair; Mutation; Organ; Outcome; PMS1 gene; PMS2 gene; Paraffin Embedding; Patients; Penetrance; Physicians; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Preparation; Prevention; Principal Investigator; Public Health; Public Health Schools; Questionnaires; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Role; Sampling; Screening procedure; Site; Source; Specimen; Testing; Time; Training; United States National Institutes of Health; Wages; Woman; base; career; colorectal cancer screening; cost; early onset; gene discovery; high risk; interest; lifetime risk; medical schools; member; mutation carrier; neoplastic; oncology; patient oriented research; professor; programs; prospective; protocol development; prototype; tumor

DESCRIPTION (provided by applicant): This K24 application has two broad goals: mentoring junior investigators in patient-oriented research and pursuing and expanding a research program in the genetics and prevention of gastrointestinal cancers. The candidate, Sapna Syngal, MD, MPH, is an Assistant Professor of Medicine at Harvard Medical School, with dual appointments in the Population Sciences Division of Dana-Farber Cancer Institute and the Gastroenterology Division at Brigham and Women's Hospital. She has established a track record at supporting and advancing the careers of physicians pursuing patient-oriented research in gastroenterology. Her current group of mentees include 14 post-doctoral fellows, all who are physicians from a variety of subspecialty backgrounds including gastroenterology, genetics, internal medicine and oncology. All mentees who have completed training with Dr. Syngal obtained a Masters in Public Health from the Harvard School of Public Health during their training period and currently hold faculty positions in academic institutions, devoting the majority of their time to pursuing patient-oriented research. Dr. Syngal is an active faculty member of a variety of NIH training grants, including a T32 in Gastroenterology, a T32 in Genetics and a R25 in Cancer Outcomes - these training grants provide salary support for the current post-doctoral fellows in Dr. Syngal's program as well as tuition costs for the MPH degree. She has been honored for mentoring by the Dana-Farber Cancer Institute Fred P Li Award for Mentoring in 2003. Dr. Syngal's research program includes evaluation of (1) screening compliance in patients at high risk for colorectal cancer; (2) the role of the mismatch repair gene, MSH6 in familial colorectal cancer; (3) the impact of genetic testing on surveillance and management of hereditary colon cancer; (4) the development of a prediction rule for mutation carriers in the MSH2 and MLH1 genes; and (5) the study of stool DMA tests and other biomarkers for early detection of colorectal cancer. Dr, Syngal is the Principal Investigator of a K07 and an RO1 award and a co-investigator on several other multi-center NIH grants. Dr. Syngal received the Young Investigator Clinical Science Award in 2004 by the American Gastroenterological Association, the, highest honor given by the AGA to one junior faculty clinical investigator nationally per year.

描述(由申请者提供)：这份K24申请有两个广泛的目标：指导初级研究人员进行以患者为导向的研究，以及继续和扩大在遗传学和胃肠道癌症预防方面的研究计划。候选人萨普娜·辛格尔，医学博士，公共卫生硕士，哈佛医学院医学助理教授，在达纳-法伯癌症研究所人口科学部和布里格姆和妇女医院的胃肠病科担任双重职务。她在支持和促进从事以患者为导向的胃肠病学研究的医生的职业生涯方面建立了良好的记录。她目前的导师小组包括14名博士后研究员，他们都是来自不同专业背景的医生，包括胃肠病学、遗传学、内科和肿瘤学。所有与辛格尔博士一起完成培训的学员都在培训期间获得了哈佛公共卫生学院的公共卫生硕士学位，目前在学术机构担任教职，将大部分时间投入到以患者为导向的研究中。辛格尔博士是NIH各种培训助学金的活跃教员，包括胃肠病学T32、遗传学T32和癌症结果R25--这些培训助学金为辛格尔博士项目中目前的博士后研究员提供工资支持，并支付公共卫生硕士学位的学费。2003年，她获得了达纳-法伯癌症研究所弗雷德·P·李导师奖的荣誉。 辛格尔博士的研究计划包括评估(1)结直肠癌高风险患者的筛查依从性；(2)错配修复基因MSH6在家族性结直肠癌中的作用；(3)基因测试对遗传性结肠癌监测和管理的影响；(4)开发MSH2和MLH1基因突变携带者的预测规则；以及(5)用于早期发现结直肠癌的粪便DMA测试和其他生物标记物的研究。辛格尔博士是K07和RO1奖项的首席研究员，也是其他几个多中心NIH赠款的联合研究员。2004年，辛格尔博士获得了美国胃肠病学会颁发的青年研究员临床科学奖，这是美国胃肠病学会每年授予全国一名初级教职临床研究员的最高荣誉。