The Genetics and Prevention of Gastrointestinal Cancers

胃肠道癌症的遗传学和预防

• 批准号: 8510390
• 负责人: SAPNA SYNGAL
• 金额: $ 19.68万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510390
• 关键词: American; Appointment; Award; Biological Markers; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Colorectal; Colorectal Cancer; Dana-Farber Cancer Institute; Data; Development; Early Detection Research Network; Early Diagnosis; Esophageal; Faculty; Family Cancer History; Funding; Gastroenterology; Gene Mutation; Genes; Genetic; Goals; Grant; Hospitals; Human; Individual; Inherited; Lead; Li-Fraumeni Syndrome; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of pancreas; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Mismatch Repair; Modeling; Mutation; Online Systems; Outcome; Patient Care; Patients; Physicians; Population Sciences; Postdoctoral Fellow; Prevention; Principal Investigator; Research; Research Design; Research Personnel; Research Project Grants; Risk Assessment; Site; Societies; Supervision; Susceptibility Gene; Syndrome; Training; United States National Institutes of Health; Woman; base; cancer genetics; carcinogenesis; career; genetic epidemiology; high risk; interest; medical schools; member; novel; patient oriented research; professor; programs; public health relevance

DESCRIPTION (provided by applicant): This K24 application has two broad goals: mentoring junior investigators in patient-oriented research, and expanding a research program in the genetics and prevention of gastrointestinal cancers. The candidate, Sapna Syngal, MD, MPH, is an Associate Professor of Medicine at Harvard Medical School, with dual appointments in the Population Sciences Division of Dana Farber Cancer Institute and the Gastroenterology Division at Brigham and Women's Hospital. She has established a track record at supporting and advancing the careers of physicians pursuing patient-oriented research in gastroenterology and cancer genetics. Her current group of mentees includes five junior faculty members, who currently have NIH research awards or are planning to apply for a NIH grant in the next few months, and four post-doctoral research fellows who are involved in active patient-oriented research projects. Dr. Syngal is also an active faculty member of a variety of NIH training grants, including a T32 in Gastroenterology, a T32 in Genetics, and a R25 in Cancer Outcomes - these training grants will continue to lead to an increasing number of post-doctoral fellows who need close supervision, guidance and mentorship. Dr. Syngal's research program consists of studies that evaluate the impact of human cancer genetics and early detection methods on patient care. These studies use a variety of clinical research designs, including genetic epidemiology, development of clinical prediction models as well as clinical trials. Ongoing projects include (1) Study of optimal methods of identification and management of patients with hereditary colorectal cancer syndromes; (2) The study of novel biomarkers involved in esophageal and colorectal carcinogenesis; (3) Search for the gene for pancreatic cancer; and (4) Study of the optimal management of patients with Li-Fraumeni syndrome. Dr. Syngal is currently the Principal Investigator of an RO1 award and co-investigator on several other multi-center NIH grants. Over the past several years, Dr. Syngal has established herself as a national leader on hereditary colorectal cancer syndrome and a valued mentor for junior investigators interested in pursuing a career in patient-oriented research. PUBLIC HEALTH RELEVANCE: Dr. Syngal's research program continues to provide essential data on phenotypic correlates of inherited mutations, assist in gene-finding endeavors, as well as define the optimal management of individuals at high risk for the development of gastrointestinal cancers. It also contributes to the increasing pool of trained clinical researchers in the field of gastrointestinal cancers and cancer genetics.

描述（由申请人提供）：该 K24 申请有两个广泛的目标：指导初级研究人员进行以患者为导向的研究，以及扩大胃肠道癌症的遗传学和预防方面的研究项目。该候选人萨普纳·辛格尔（Sapna Syngal），医学博士、公共卫生硕士，是哈佛医学院的医学副教授，在达纳法伯癌症研究所人口科学部和布莱根妇女医院胃肠病学部双重任命。她在支持和促进从事胃肠病学和癌症遗传学领域以患者为导向的研究的医生的职业生涯方面建立了良好的记录。她目前的学员包括五名初级教员，他们目前拥有 NIH 研究奖项或计划在未来几个月内申请 NIH 资助，以及四名积极参与以患者为导向的研究项目的博士后研究员。 Syngal 博士还是 NIH 各种培训补助金的活跃教员，包括胃肠病学 T32、遗传学 T32 和癌症结果 R25 - 这些培训补助金将继续导致越来越多需要密切监督、指导和指导的博士后研究员。 Syngal 博士的研究项目包括评估人类癌症遗传学和早期检测方法对患者护理的影响的研究。这些研究采用各种临床研究设计，包括遗传流行病学、临床预测模型的开发以及临床试验。正在进行的项目包括（1）研究遗传性结直肠癌综合征患者识别和管理的最佳方法； （2）食管癌、结直肠癌发生过程中新型生物标志物的研究； （3）寻找胰腺癌基因； (4)Li-Fraumeni综合征患者优化治疗的研究。 Syngal 博士目前是 RO1 奖项的首席研究员和其他几项 NIH 多中心资助的联合研究员。 在过去的几年里，Syngal 博士已成为遗传性结直肠癌综合征领域的全国领导者，也是有兴趣从事以患者为导向的研究的初级研究人员的宝贵导师。 公共健康相关性：Syngal 博士的研究项目继续提供有关遗传突变表型相关性的重要数据，协助基因寻找工作，并确定对胃肠道癌症高风险个体的最佳管理。它还有助于增加胃肠道癌症和癌症遗传学领域训练有素的临床研究人员的数量。