IN VIVO SELECTION OF LIGANDS FOR TARGETED THERAPY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to develop a method to substantially increase the dose of anticancer drugs directly to a cancer while decreasing the dose to normal body tissue. We propose to develop a tag, a peptide, to be added to the anticancer drug, which would allow the anticancer drug to be delivered and concentrated at cancer cells. The purpose of this study is to develop the tag that will attach to the "address" of cancer cells. In a future study the targeting agent (tag) will be designed to deliver anticancer drugs directly to the address of the cancer cells. We propose to intravenously inject several million different tags. A small piece of the cancer is removed and the tags that have found their way to the cancer cells and are able to stick at the address of cancer cells will be determined.