METABOLIC CONSEQUENCE OF SICKLE CELL ANEMIA IN ADOLESCENCE

青少年镰状细胞贫血症的代谢后果

• 批准号: 7605530
• 负责人: MACIEJ S BUCHOWSKI
• 金额: $ 0.9万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605530
• 关键词: Adolescence; Adolescent; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Daily; Energy Metabolism; Funding; Grant; Growth; Institution; Metabolic; Pathway interactions; Physical activity; Proteins; Rate; Research; Research Personnel; Resources; Sickle Cell Anemia; Source; United States National Institutes of Health; protein degradation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: The central hypothesis of this GCRC proposal is that increased whole-body protein turnover and increased cardiac output, resulting in increased energy expenditure for basal needs and physical activity, divert energy and protein from normal growth pathways in HbSS adolescents. SPECIFIC AIMS: 1) To determine how much energy and protein is needed for optimal growth in adolescents w/HbSS. 2) To explain how growth rate in HbSS adolescents is altered by increased demands for energy caused by higher whole-body protein turnover and increased cardiac output. 3) To quantify how much energy and protein is required for daily physical activity in adolescents w/HbSS.

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