METABOLIC CONSEQUENCE OF SICKLE CELL ANEMIA IN ADOLESCENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 假设： GCRC建议的中心假设是，HbSS青少年全身蛋白质周转增加和心输出量增加，导致基本需求和体力活动的能量消耗增加，转移了HbSS青少年正常生长过程中的能量和蛋白质。 具体目标： 1)确定HbSS青少年的最佳生长所需的能量和蛋白质。 2)解释HbSS青少年的生长速度是如何因全身蛋白质周转增加和心输出量增加而增加的能量需求而改变的。3)量化HbSS青少年日常体力活动所需的能量和蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: The central hypothesis of this GCRC proposal is that increased whole-body protein turnover and increased cardiac output, resulting in increased energy expenditure for basal needs and physical activity, divert energy and protein from normal growth pathways in HbSS adolescents. SPECIFIC AIMS: 1) To determine how much energy and protein is needed for optimal growth in adolescents w/HbSS. 2) To explain how growth rate in HbSS adolescents is altered by increased demands for energy caused by higher whole-body protein turnover and increased cardiac output. 3) To quantify how much energy and protein is required for daily physical activity in adolescents w/HbSS.