METABOLIC CONSEQUENCE OF SICKLE CELL ANEMIA IN ADOLESCENCE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 假设： 该GCRC提案的中心假设是，全身蛋白质周转增加和心输出量增加，导致基础需求和体力活动的能量消耗增加，将能量和蛋白质从HbSS青少年的正常生长途径转移。 具体目标： 1)确定HbSS青少年的最佳生长需要多少能量和蛋白质。 2)解释HbSS青少年的生长率如何因全身蛋白质周转率升高和心输出量增加引起的能量需求增加而改变。 3)量化HbSS青少年每日体力活动所需的能量和蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: The central hypothesis of this GCRC proposal is that increased whole-body protein turnover and increased cardiac output, resulting in increased energy expenditure for basal needs and physical activity, divert energy and protein from normal growth pathways in HbSS adolescents. SPECIFIC AIMS: 1) To determine how much energy and protein is needed for optimal growth in adolescents w/HbSS. 2) To explain how growth rate in HbSS adolescents is altered by increased demands for energy caused by higher whole-body protein turnover and increased cardiac output. 3) To quantify how much energy and protein is required for daily physical activity in adolescents w/HbSS.