HYDROXYCHOLOQUINE IN CYSTIC FIBROSIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 待检验的假设是，CF患者治疗4周后，羟氯喹将减少诱导痰中的嗜中性粒细胞、活性弹性蛋白酶和促炎细胞因子（不增加细菌负荷），并将增加在相同时间点收集的呼出气冷凝液（EBC）的pH值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis to be tested is that hydroxychloroquine will reduce neutophils, active elastase, ad proinflammatory cytokines (without and increase in bacterial burden) in induced sputum after 4 weeks of therapy in patients with CF, and that it will increase the pH of exhaled breath condensate (EBC) collected at the same time points.