GUT MICROBIOTA AND HUMAN ENERGY EXPENDITURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 假设： 我们建议在一小群健康的正常志愿者中进行实验，以验证我们的主要假设：微生物区系诱导人类总EE及其组成部分(特别是静息EE)显着增加。 特定目标： 1.测定灌肠前后的全身能量消耗。 2.确定微生物区系在静息EE、DIT和活动EE中的贡献。 3.如果我们的假设是正确的，那么我们将致力于确定微生物区系在确定瘦人和肥胖者之间的能量差异方面的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: We propose to conduct an experiment in a small group of healthy normal volunteers to test our primary hypothesis: microbiota induces a significant increase in total EE and its components (particularily in resting EE) in humans. Specific Aimes: 1. To determine the whole-body energy expenditure before and after bowel clensing. 2. To define the contributions of microbiota in resting EE, DIT, and activity EE. 3. If our hypothesis is correct, we will then aim to determine the influence of the microbiota in determining energetic differences between lean and obese individuals.