DYSLIPIDEMIA IN CHRONIC KIDNEY DISEASE

慢性肾脏病中的血脂异常

• 批准号: 7605347
• 负责人: JEFFREY M SALAND
• 金额: $ 0.18万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605347
• 关键词: Apolipoproteins C; Cardiovascular Diseases; Catabolism; Child; Childhood; Chronic Kidney Failure; Chronic Kidney Insufficiency; Computer Retrieval of Information on Scientific Projects Database; Dyslipidemias; End stage renal failure; Fasting; Fatty acid glycerol esters; Funding; Genetic; Grant; Hypertriglyceridemia; Individual; Institution; Insulin Resistance; Kidney Failure; Lipoproteins; Metabolism; Play; Research; Research Personnel; Resources; Role; Source; Triglycerides; United States National Institutes of Health; apolipoprotein C-III; insulin sensitivity; response; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Individuals developing chronic kidney disease (CKD) during childhood develop premature and accelerated cardiovascular disease, particularly those who progress to end-stage renal disease (ESRD)(1-6). Dyslipidemia may play a role both in the progression of CKD itself and in the genesis of cardiovascular disease. Hypertriglyceridemia develops with chronic renal insufficiency (CRI) in large part due to impaired triglyceride catabolism. Certain factors appear to promote this abnormality, including elevated apolipoprotein (apo) C-III and altered insulin sensitivity. The post-prandial response to a high-fat mixed meal is an experimental approach well suited to the study of lipoprotein metabolism and insulin sensitivity in CRI. Hypothesis: Children and young adults with CRI have delayed post-prandial triglyceride clearance. Secondary hypotheses include: post-prandial triglyceride clearance is related to fasting triglyceride levels, insulin resistance, apoC-III levels, the degree of renal insufficiency, and specific genetic influences.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 儿童期在儿童时期发展慢性肾脏疾病（CKD）的人会发展早产和加速心血管疾病，尤其是那些发展为终末期肾脏疾病（ESRD）的人（1-6）。 血脂血症可能在CKD本身的进展和心血管疾病的起源中发挥作用。 高甘油三酸酯血症在慢性肾功能不全（CRI）的发展很大程度上是由于甘油三酸酯分解代谢受损。 某些因素似乎促进了这种异常，包括升高的载脂蛋白（APO）C-III和胰岛素敏感性改变。 对高脂混合餐的餐后反应是一种实验方法，非常适合研究CRI中脂蛋白代谢和胰岛素敏感性的研究。 假设： 患有CRI的儿童和年轻人延迟了餐后甘油三酸酯的清除。 次要假设包括：后甘油三酸酯清除率与禁食甘油三酸酯水平，胰岛素抵抗，APOC-III水平，肾脏不足程度和特定的遗传影响有关。