FORMOCRESOL BLOOD LEVELS IN CHILDREN RECEIVING DENTAL TREATMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 甲酚是一种常用的药物，用于治疗需要治疗性的、重要的牙髓切断术的乳牙。重要的牙髓切断术是指对乳牙进行部分根管治疗，手术切除神经的冠状部分，并用甲酚等药物固定最冠状的牙髓组织残端。在乳牙中，重要的牙髓切断术通常也被称为“牙髓疗法”。尽管已知的事实是，在较高的全身浓度下，甲醛甲酚具有致突变、致癌和毒性的潜力，但没有关于人类牙髓切断术治疗后全身摄取(血浆浓度)的数据。因此，这项研究的目的是确定在全麻下接受包括牙髓治疗的综合口腔康复治疗的儿童中，甲醛甲酚的存在(如果有)和基于时间的血浆浓度。我们的目标是将大约40名受试者纳入这项研究，以获得30组最终/可用的数据。这项研究的受试者将被分成两组：低剂量甲醛甲酚(3颗或更少的牙齿进行牙髓切除)和高剂量的甲醛甲酚(4颗或更多的牙齿进行牙髓切除)。虽然这些都是人工的和手术确定的剂量，但应该注意的是，定期对儿童乳牙进行4次或更多的甲醛甲酚拔髓是标准的操作程序。血清样本将从所有全身麻醉过程中放置的静脉导管中提取，并分析甲醛甲酚的浓度。这项研究的结果数据将有助于为牙科使用甲醛甲酚建立适当的指南，并使其与先前的动物研究更相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formocresol is a medicament commonly used in the treatment of primary teeth requiring therapeutic, vital pulpotomy. A vital pulpotomy refers to partial root canal therapy in primary teeth wherein the coronal portion of the nerve is surgically removed and the most coronal stump of pulp tissue is fixed with a medicament such as formocresol. A vital pulpotomy is also often referred to as "pulp therapy" in primary teeth. Despite the fact that in high systemic concentrations formocresol has known mutagenic, carcinogenic, and toxic potential, no data exists regarding systemic uptake (plasma concentration) after pulpotomy treatment in humans. Thus, the purpose of this study is to determine the existence, if any, and time-based plasma concentration of formocresol in children undergoing comprehensive oral rehabilitation involving pulp therapy under general anesthesia. We aim to enroll approximately 40 subjects into this study to attain 30 final/useable sets of data. Subjects for this study will be divided into two groups: low dose formocresol (3 or less teeth receiving pulpotomy) and high dose formocresol (4 or more teeth receiving pulpotomy). Although these are artificial and operationally defined doses, it should be noted that it is standard operating procedure to do 4 or more formocresol pulpotomies on primary teeth in children on a regular basis. Serum specimens will be drawn from an intravenous catheter placed during all general anesthesia procedures and analyzed for concentration of formocresol. The resulting data from this study will help to establish appropriate guidelines for the use of formocresol in dentistry and to make correlation with previous animal studies more relevant.