WELL-NOURISHED AND SLEEPING PRETERM INFANT IMPROVED BRAIN DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项由非营利性基金支持的针对极低出生体重(VLBW)早产儿的前瞻性对照临床试验。我们认为，母乳的营养补充(以及改善感觉环境)可以改善早产儿的生长和大脑发育。我们的目标是改善极低出生体重早产儿的营养、睡眠、生长和脑发育，以及以后的神经发育结果。我们认为，改善营养的基础是：(1)测定母乳中的蛋白质和卡路里含量，以及(2)根据所测得的含量强化母乳。额外营养素的数量必须根据所确定的被强化牛奶的含量进行个体化。通过这种方式，可以确保蛋白质和卡路里的摄入量保持在目标水平。我们还相信，循环的光和声环境以及在喂养过程中呈现母亲的乳香也可能对婴儿有利。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective, controlled clinical trial in very low birth weight (VLBW) preterm infants supported by non profit fundations. We propose that nutritional supplementation of breast milk (and a modified sensory environment) can improve growth and brain development of preterm infants. Our goal is to improve the nutrition, quantity of sleep, growth and brain development plus later neuro-developmental outcomes of VLBW preterm infants. We believe that improved nutrition is based on: (1) determination of the protein and calorie content of breast milk, and (2) fortification of mother's breast milk based on the measured contents. The amounts of additional nutrients must be individualized, based on the determined content of the milk that is being fortified. In this way it is possible to ensure that protein and calorie intake remains at a target level. We also believe that cycled light and sound environment and presentation of the mother's milk scent during feeding may also benefit the infant.