New Approach to Detect CP and Brain Injury by Term Age

按足龄检测脑瘫和脑损伤的新方法

• 批准号: 6639672
• 负责人: RONALD Lee ARIAGNO
• 金额: $ 19.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-20 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639672
• 关键词: brain injury; cerebral palsy; clinical research; diagnosis design /evaluation; early diagnosis; electroencephalography; gestational age; human subject; low birth weight infant human; magnetic resonance imaging; nervous system disorder diagnosis; neuropsychological tests; noninvasive diagnosis

DESCRIPTION (provided by applicant): There have been significant advances in medical technology and care for critically ill neonates over the last 3 decades. Survival of very low birth weight infants (VLBW), at a significant national health cost and family hardship, is now a reality. Furthermore, the number of VLBW preterm infants has begun to increase due to advances in the science of fertility and increasing maternal age. The long term neurological morbidity for these lowest weight and gestational age infants is increased. The incidence of handicap in this population has changed little over the past decades. VLBW preterm infants constitute 25% of all children with cerebral palsy (CP). Currently, we lack diagnostic techniques to identify brain injury such as CP early (i.e., around corrected term age). Although the brain injury is present from early neonatal period, it takes 1-2 years before the disease is neurologically manifested. Thus, our ability to learn more about causes, prevention, and treatment is currently very limited. This proposal utilizes state-of-the-art MRI technology to predict those preterm infants who will develop CP. This innovative proposal concerns a timely pediatric problem of critical importance to pediatricians, neonatologists, pediatric neurologists, radiologists and MR physicists. Using quantitative MRI, EEG, and neurobehavioral tests we hope to be able to identify infants at risk for CP as early as 37 weeks post conceptional age. The collaboration between neonatal, neurological, and neuroimaging expertise is integral for an advance in our knowledge of detecting neonatal neurobiological pathology prior to 1-2 years of age. It is essential to discover a new approach to identify brain injury early, before it will be possible to effectively investigate interventions that can improve neurological outcome of these high risk very premature infants.

描述（由申请人提供）：在以下方面取得了重大进展： 过去 3 年危重新生儿的医疗技术和护理 几十年。极低出生体重婴儿 (VLBW) 的存活率显着提高 国民健康成本和家庭困难，现已成为现实。此外， 由于科学技术的进步，VLBW早产儿的数量开始增加 生育科学和增加产妇年龄。长期神经系统 这些体重和胎龄最低的婴儿的发病率有所增加。这 该人群的残疾发生率与过去相比几乎没有变化 几十年。极低出生体重早产儿占脑脑病患儿的 25% 麻痹（CP）。目前，我们缺乏识别脑损伤的诊断技术 例如 CP 早期（即大约校正足龄）。虽然脑部受伤 从新生儿早期就存在，需要1-2年才能发病。 神经学上表现出来的。因此，我们有能力更多地了解原因， 目前的预防和治疗非常有限。本提案利用 最先进的 MRI 技术可预测早产儿的出生情况 发展CP。这项创新提案涉及一个及时的儿科问题 对儿科医生、新生儿科医生、儿科神经科医生至关重要， 放射科医生和 MR 物理学家。使用定量 MRI、EEG 和 我们希望通过神经行为测试能够识别出有脑瘫风险的婴儿 早在受孕后 37 周。新生儿之间的合作， 神经学和神经影像学专业知识对于我们的进步至关重要 1-2 岁之前检测新生儿神经生物学病理学的知识 年龄。发现一种早期识别脑损伤的新方法至关重要， 才能有效地调查干预措施 改善这些高风险早产儿的神经系统结果。

项目成果

Diffusion tensor brain imaging findings at term-equivalent age may predict neurologic abnormalities in low birth weight preterm infants.

足月当量年龄的弥散张量脑成像结果可以预测低出生体重早产儿的神经系统异常。

• 发表时间: 2003
• 期刊: AJNR. American journal of neuroradiology
• 作者: Arzoumanian,Y;Mirmiran,M;Barnes,PD;Woolley,K;Ariagno,RL;Moseley,ME;Fleisher,BE;Atlas,SW
• 通讯作者: Atlas,SW