New Approach to Detect CP and Brain Injury by Term Age

描述(由申请人提供)：在以下方面取得了重大进展 过去3年对危重新生儿的医疗技术和护理 几十年。极低出生体重儿(VLBW)的存活率显著 国民健康成本和家庭困难，现在已经成为现实。此外， 极低出生体重早产儿的数量已经开始增加，这是由于 关于生育和增加产妇年龄的科学。长期的神经学 这些体重和胎龄最低的婴儿的发病率会增加。这个 这一人群的残障发生率在过去几乎没有变化。 几十年。极低出生体重儿占所有脑性早产儿的25% 瘫痪(CP)。目前，我们缺乏识别脑损伤的诊断技术。 例如CP早期(即大约纠正的足月年龄)。虽然脑部损伤 从新生儿早期就开始出现，需要1-2年时间才会出现 神经学上表现出来的。因此，我们了解更多原因的能力， 预防和治疗目前非常有限。这项建议利用了 最先进的核磁共振技术可以预测早产儿 发展CP。这项创新的建议涉及到及时的儿科问题 对儿科医生、新生儿科医生、儿科神经科医生至关重要， 放射科医生和核磁共振物理学家。使用定量MRI、EEG和 我们希望神经行为测试能够将有脑瘫风险的婴儿识别为 早在怀孕后37周。新生儿之间的合作， 神经学和神经成像专业知识对于我们的 新生儿出生前1~2年神经生物学病理检测知识的掌握 年龄。发现一种新的方法来早期识别脑损伤是至关重要的， 在能够有效地调查可以 改善这些高危早产儿的神经结局。

DESCRIPTION (provided by applicant): There have been significant advances in medical technology and care for critically ill neonates over the last 3 decades. Survival of very low birth weight infants (VLBW), at a significant national health cost and family hardship, is now a reality. Furthermore, the number of VLBW preterm infants has begun to increase due to advances in the science of fertility and increasing maternal age. The long term neurological morbidity for these lowest weight and gestational age infants is increased. The incidence of handicap in this population has changed little over the past decades. VLBW preterm infants constitute 25% of all children with cerebral palsy (CP). Currently, we lack diagnostic techniques to identify brain injury such as CP early (i.e., around corrected term age). Although the brain injury is present from early neonatal period, it takes 1-2 years before the disease is neurologically manifested. Thus, our ability to learn more about causes, prevention, and treatment is currently very limited. This proposal utilizes state-of-the-art MRI technology to predict those preterm infants who will develop CP. This innovative proposal concerns a timely pediatric problem of critical importance to pediatricians, neonatologists, pediatric neurologists, radiologists and MR physicists. Using quantitative MRI, EEG, and neurobehavioral tests we hope to be able to identify infants at risk for CP as early as 37 weeks post conceptional age. The collaboration between neonatal, neurological, and neuroimaging expertise is integral for an advance in our knowledge of detecting neonatal neurobiological pathology prior to 1-2 years of age. It is essential to discover a new approach to identify brain injury early, before it will be possible to effectively investigate interventions that can improve neurological outcome of these high risk very premature infants.