FASEB Summer Conference on Nuclear Structure and Cancer

描述(由申请人提供)：本申请是为了资助将于2007年6月16-21日在佛蒙特州萨克斯顿河的佛蒙特学院举行的第四届和第五届FASB夏季“核结构与癌症”研究会议的部分资金。这些会议是在美国实验生物学学会联合会(FASE B)的赞助下举行的。对于这两个会议，都将有9个平台会议，一个关于活细胞和动物模型的分子成像的研讨会，以及两个海报会议。将鼓励青年研究人员从提交的摘要中挑选，在定期平台和研讨会上作简短发言。这些会议将汇集来自学术界和私营部门的基础和临床研究人员，重点了解改变的核结构在癌症过程中的作用。这些会议将提供论坛，以评估控制肿瘤细胞核内基因复制、修复和表达的核酸和调控蛋白的修饰的时间和空间组织的基本调控和临床意义。从基础生物学和临床的角度研究与肿瘤相关的核形态变化和亚核组织、核输入、核内转运和调控因子的组装正变得越来越重要。有必要召开这次会议，专门研究因癌症的发生和发展而在结构和功能上受到损害的细胞中间期核的结构和功能特性。本课程将系统地探讨核形态与基因复制、修复和表达之间的相互关系。将共同努力对新出现的发现进行批判性评估，这些发现将核组织与管理基因组功能组合控制的调控机制组合在一起。将讨论表观遗传调控机制。将考虑细胞、生化、体内遗传和分子方法的贡献，并将它们整合到多学科战略中，以了解基因组组织、功能和癌症之间的相互关系。 相关性：这些会议的目标将是开发包含新概念和高分辨率最新方法的实验议程，以定义与癌细胞中基因复制、修复和表达调控变化相关的核结构扰动。预期对核组织成分的洞察是现实的，这些成分可以选择性地作为创新的癌症诊断和治疗的靶点。

DESCRIPTION (provided by applicant): This application is for partial funding of the fourth and fifth FASEB Summer Research Conferences on "Nuclear Structure and Cancer" that will be held June 16-21, 2007 and in 2009, at the Vermont Academy in Saxtons River, Vermont. The conferences are under the auspices of the Federation of American Societies for Experimental Biology (FASEB). For both conferences, there will be 9 platform sessions, a workshop on molecular imaging in living cells and animal models and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. The meetings will bring together basic and clinical investigators from academia and the private sector to focus on understanding the role of altered nuclear structure in the cancer process. These conferences will provide forums to evaluate the fundamental regulatory and clinical implications of modified temporal and spatial organization of nucleic acids and regulatory proteins that control gene replication, repair and expression in nuclei of tumor cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization, nuclear import, intranuclear trafficking and assembly of regulatory factors is becoming increasingly relevant from both basic biological and clinical perspectives. There is a need for this conference that is dedicated to examining the structural and functional properties of the interphase nucleus in cells that are structurally and functionally compromised with the onset and progression of cancer. Mechanisms that interrelate nuclear morphology with gene replication, repair and expression will be systematically explored. There will be a concerted effort to critically evaluate emerging findings that interface nuclear organization with the assembly of regulatory machinery that governs the combinatorial control of genomic function. Epigenetic regulatory mechanisms will be addressed. Consideration will be given to contributions from cellular, biochemical, in vivo genetic and molecular approaches and their integration into multidisciplinary strategies for understanding the interrelationships among genomic organization, function, and cancer. Relevance: The objective of these meetings will be to develop experimental agendas that incorporate novel concepts and high resolution state-of-the-art methodologies for defining perturbations in nuclear architecture that are related to changes in the regulation of gene replication, repair, and expression in cancer cells. It is realistic to anticipate insight into components of nuclear organization that can be selectively targeted for innovative cancer diagnosis and therapy.