FASEB Summer Conference on Nuclear Structure and Cancer

描述（由申请人提供）：本申请是为第四届和第五届FASEB“核结构与癌症”夏季研究会议提供部分资金，该会议将于2007年6月16日至21日和2009年在佛蒙特州萨克斯顿河的佛蒙特学院举行。这些会议由美国实验生物学学会联合会（FASEB）主办。这两个会议将有9个平台会议，一个关于活细胞和动物模型分子成像的研讨会和两个海报会议。青年研究人员将从提交的摘要中挑选，鼓励他们在定期平台和研讨会上做简短的演讲。会议将汇集来自学术界和私营部门的基础和临床研究人员，重点了解核结构改变在癌症过程中的作用。这些会议将提供论坛，以评估控制肿瘤细胞核中基因复制、修复和表达的核酸和调节蛋白的修改时空组织的基本调节和临床意义。从基础生物学和临床角度来看，研究肿瘤相关的核形态变化和亚核组织、核输入、核内运输和调节因子的组装正变得越来越重要。有必要召开这次会议，专门研究细胞间期核的结构和功能特性，这些细胞核在结构和功能上受到癌症的发生和发展的损害。本课程将系统探讨核形态与基因复制、修复和表达的相关机制。将会有一个协调一致的努力来批判性地评估新发现，这些发现将核组织与控制基因组功能组合控制的调节机制的组装结合起来。将讨论表观遗传调控机制。将考虑到细胞，生化，体内遗传和分子方法的贡献，并将其整合到多学科策略中，以理解基因组组织，功能和癌症之间的相互关系。

DESCRIPTION (provided by applicant): This application is for partial funding of the fourth and fifth FASEB Summer Research Conferences on "Nuclear Structure and Cancer" that will be held June 16-21, 2007 and in 2009, at the Vermont Academy in Saxtons River, Vermont. The conferences are under the auspices of the Federation of American Societies for Experimental Biology (FASEB). For both conferences, there will be 9 platform sessions, a workshop on molecular imaging in living cells and animal models and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. The meetings will bring together basic and clinical investigators from academia and the private sector to focus on understanding the role of altered nuclear structure in the cancer process. These conferences will provide forums to evaluate the fundamental regulatory and clinical implications of modified temporal and spatial organization of nucleic acids and regulatory proteins that control gene replication, repair and expression in nuclei of tumor cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization, nuclear import, intranuclear trafficking and assembly of regulatory factors is becoming increasingly relevant from both basic biological and clinical perspectives. There is a need for this conference that is dedicated to examining the structural and functional properties of the interphase nucleus in cells that are structurally and functionally compromised with the onset and progression of cancer. Mechanisms that interrelate nuclear morphology with gene replication, repair and expression will be systematically explored. There will be a concerted effort to critically evaluate emerging findings that interface nuclear organization with the assembly of regulatory machinery that governs the combinatorial control of genomic function. Epigenetic regulatory mechanisms will be addressed. Consideration will be given to contributions from cellular, biochemical, in vivo genetic and molecular approaches and their integration into multidisciplinary strategies for understanding the interrelationships among genomic organization, function, and cancer. Relevance: The objective of these meetings will be to develop experimental agendas that incorporate novel concepts and high resolution state-of-the-art methodologies for defining perturbations in nuclear architecture that are related to changes in the regulation of gene replication, repair, and expression in cancer cells. It is realistic to anticipate insight into components of nuclear organization that can be selectively targeted for innovative cancer diagnosis and therapy.