FASEB Summer Conference on Nuclear Structure and Cancer

描述（由申请人提供）：本申请是为将于2007年6月16日至21日和2009年在佛蒙特州萨克顿河的佛蒙特学院举行的关于"核结构与癌症"的第四届和第五届FASEB夏季研究会议提供部分资金。会议由美国实验生物学学会联合会（FASEB）主办。这两个会议将有9个平台会议，一个活细胞和动物模型分子成像研讨会和两个海报会议。将鼓励年轻的研究人员从提交的摘要中挑选，在定期的平台和讲习班会议上作简短的发言。会议将汇集来自学术界和私营部门的基础和临床研究人员，重点了解改变的核结构在癌症过程中的作用。这些会议将提供论坛，以评估修改的时间和空间组织的核酸和调节蛋白，控制基因复制，修复和表达在肿瘤细胞核中的基本监管和临床意义。从基础生物学和临床角度来看，对肿瘤相关的核形态学和亚核组织、核输入、核内运输和调节因子组装变化的研究正变得越来越重要。有一个需要这个会议，是专门检查的结构和功能特性的间期核细胞的结构和功能与癌症的发病和进展受到损害。将系统地探讨核形态与基因复制、修复和表达之间的相互关系。将有一个协调一致的努力，严格评估新的发现，接口核组织与大会的监管机制，管理基因组功能的组合控制。表观遗传调控机制将得到解决。将考虑从细胞，生物化学，在体内遗传和分子的方法和它们的整合到多学科的战略，了解基因组组织，功能和癌症之间的相互关系的贡献。 相关性：这些会议的目标将是制定实验议程，纳入新的概念和高分辨率的最先进的方法，用于定义与癌细胞中基因复制，修复和表达调控变化相关的核结构扰动。这是现实的预期洞察核组织的组成部分，可以选择性地针对创新的癌症诊断和治疗。

DESCRIPTION (provided by applicant): This application is for partial funding of the fourth and fifth FASEB Summer Research Conferences on "Nuclear Structure and Cancer" that will be held June 16-21, 2007 and in 2009, at the Vermont Academy in Saxtons River, Vermont. The conferences are under the auspices of the Federation of American Societies for Experimental Biology (FASEB). For both conferences, there will be 9 platform sessions, a workshop on molecular imaging in living cells and animal models and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. The meetings will bring together basic and clinical investigators from academia and the private sector to focus on understanding the role of altered nuclear structure in the cancer process. These conferences will provide forums to evaluate the fundamental regulatory and clinical implications of modified temporal and spatial organization of nucleic acids and regulatory proteins that control gene replication, repair and expression in nuclei of tumor cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization, nuclear import, intranuclear trafficking and assembly of regulatory factors is becoming increasingly relevant from both basic biological and clinical perspectives. There is a need for this conference that is dedicated to examining the structural and functional properties of the interphase nucleus in cells that are structurally and functionally compromised with the onset and progression of cancer. Mechanisms that interrelate nuclear morphology with gene replication, repair and expression will be systematically explored. There will be a concerted effort to critically evaluate emerging findings that interface nuclear organization with the assembly of regulatory machinery that governs the combinatorial control of genomic function. Epigenetic regulatory mechanisms will be addressed. Consideration will be given to contributions from cellular, biochemical, in vivo genetic and molecular approaches and their integration into multidisciplinary strategies for understanding the interrelationships among genomic organization, function, and cancer. Relevance: The objective of these meetings will be to develop experimental agendas that incorporate novel concepts and high resolution state-of-the-art methodologies for defining perturbations in nuclear architecture that are related to changes in the regulation of gene replication, repair, and expression in cancer cells. It is realistic to anticipate insight into components of nuclear organization that can be selectively targeted for innovative cancer diagnosis and therapy.