FASEB Summer Conference on Phospholipases

FASEB 磷脂酶夏季会议

• 批准号: 7614204
• 负责人: Suzanne F Scarlata
• 金额: --
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7614204
• 关键词: 1,2-diacylglycerol; Actins; Agonist; Apoptosis; Arachidonic Acids; Area; Asthma; Biology; Biophysics; Cell Surface Receptors; Cell physiology; Cellular Stress Response; Clinical; Collaborations; Cytoprotection; Cytoskeleton; Development; Diglycerides; Discipline; Enzymes; Esters; Fatty Acids; Funding; Goals; Hemostatic function; Host Defense; Hydrolysis; Inflammation; Inositol Phosphates; Institutes; International; Kidney; Lecithin; Leukotrienes; Lipids; Lysophospholipids; Malignant Neoplasms; Membrane; Molecular and Cellular Biology; Pathologic Processes; Perfusion; Phosphatidic Acid; Phospholipase; Phospholipase C; Phospholipase D; Phospholipases A; Phospholipids; Physiological; Prostaglandins; Publications; Research; Research Peer Review; Research Personnel; Rivers; Role; Scientist; Second Messenger Systems; Signal Transduction; Sphingolipids; Stomach; Structure; Travel; United States National Institutes of Health; Vermont; Work; cell growth; cell motility; drug development; phosphodiester; posters; receptor; response; second messenger; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the eighth FASEB Summer Research Conference on Phospholipases to be held from July 8 to 13, 2006 in Saxtons River, Vermont. The funds requested will be used primarily to support the registration and travel expenses of junior investigators who will present their work at the conference as invited presentations, short talks, or posters. The overall goal of this established and successful conference is to provide a forum for review and discussion of recent research on the structure, function and integrated biology of phospholipases. These widely expressed enzymes hydrolyze ester and phosphodiester bonds in membrane phospholipids to generate bioactive lipids and lipid-derived products that regulated many and diverse aspects of cell function. Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma. Phospholipase C generates inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors. Phospholipase D generates phosphatidic acid from phosphatidylcholine, to regulate organization of the actin cytoskeleton, cell growth, survival, motility and vesicular transport. The conference includes talks on the emerging areas of signaling networks and lipidomics as well as sphingolipids, which have roles in cellular stress responses, apoptosis, and cell migration. This conference brings together scientists working in diverse disciplines including biophysics, structural, cell and molecular biology, drug development, and diverse clinical disciplines that are impacted by research on phospholipases. The conference has a strong record of including contributions from international investigators and of including presentations from both junior and established investigators. It provides an effective forum for promoting collaborations and new advances in the field. The subject area receives considerable support from the NIH with approximately 400 active projects funded by each of the major NIH institutes. The field has generated approximately 2000 peer reviewed research publications in each of the last 10 years. The funds requested in this proposal will make an invaluable contribution to the support of this conference and in particular the development of young investigators.

描述（由申请人提供）： 本申请寻求将于2006年7月8日至13日在佛蒙特州的萨克顿河举行的第八届FASEB磷脂酶夏季研究会议的部分资金。申请的资金将主要用于支付初级调查员的登记和差旅费，他们将应邀在会议上作报告、简短演讲或张贴海报。这个既定的和成功的会议的总体目标是提供一个论坛，审查和讨论磷脂酶的结构，功能和综合生物学的最新研究。这些广泛表达的酶水解膜磷脂中的酯键和磷酸二酯键，以产生调节细胞功能的许多不同方面的生物活性脂质和脂质衍生产物。磷脂酶A产生脂肪酸和受体活性溶血磷脂。花生四烯酸被代谢为白三烯和白藜芦醇，它们在生理和病理过程中具有良好的作用，如肾灌注、胃细胞保护、止血、癌症、宿主防御、炎症和哮喘。磷脂酶C响应于细胞表面受体的激动剂活化而产生肌醇磷酸和甘油二酯第二信使。磷脂酶D从磷脂酰胆碱产生磷脂酸，以调节肌动蛋白细胞骨架的组织、细胞生长、存活、运动和囊泡运输。会议包括信号网络和脂质组学以及鞘脂的新兴领域的会谈，鞘脂在细胞应激反应，凋亡和细胞迁移中发挥作用。本次会议汇集了在不同学科工作的科学家，包括生物物理学，结构，细胞和分子生物学，药物开发，以及受磷脂酶研究影响的不同临床学科。会议有一个强大的记录，包括国际调查人员的贡献，并包括初级和成熟的调查人员的介绍。它为促进该领域的合作和新进展提供了一个有效的论坛。该主题领域得到了NIH的大力支持，每个主要的NIH研究所资助了大约400个活跃的项目。在过去的10年中，该领域每年产生约2000份同行评审的研究出版物。本提案所要求的资金将对支持这次会议，特别是对培养年轻调查人员作出宝贵贡献。