PORTABLE VOLUME MEASURING DEVICE TO PREDICT NEED FOR RESPIRATORY SUPPORT IN NEWB

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 增加使用产前类固醇，表面活性剂，沿着机械通气，改善了早产儿的结局。然而，可能过度使用机械呼吸机可能导致创伤和慢性肺部疾病。有一些建议，一些早产儿可能会有更好的结果，如果不插管出生时，但放置在鼻持续气道正压通气（CPAP）。目前，对于哪些婴儿应该在出生时进行CPAP或插管，还没有共识的指导方针。一个生理测量，如自发呼出量，可能能够提供指导新生儿呼吸窘迫的治疗过程。本研究的目的是确定商业便携式肺功能测量设备是否可以用于预测出生后不久对呼吸支持和表面活性剂的需求。这将是一项前瞻性、观察性研究。测量结果不会透露给临床团队，他们将根据自己的判断来决定患者的护理过程。结局将包括呼吸支持程度和表面活性剂治疗。我们计划招募约100名患者，其中50名出生体重低于1500克。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increased use of antenatal steroids, surfactant, along with mechanical ventilation, has improved outcomes for premature infants. However, the possible overuse of mechanical ventilators may lead to trauma and chronic lung disease. There is some suggestion that some premature infants may have better outcomes if not intubated at birth, but placed on nasal continuous positive airway pressure (CPAP). At present, there are no consensus guidelines on which infants should be placed on CPAP at birth or intubated. A physiologic measurement, such as spontaneous exhaled volume, may be able to provide guidance in treatment course for newborns with respiratory distress. The aim of this study is to determine if a commercial portable pulmonary function measurement device can be used to predict the need for respiratory support and surfactant soon after birth. This will be a prospective, observational study. The measurements will not be revealed to the clinical team, who will use their judgment in deciding the patient's course of care. Outcomes will include degree of respiratory support and surfactant therapy. We plan to enroll approximately 100 patients, 50 below 1500 grams birth weight.