PREDICT NEED FOR RESPIRATORY SUPPORT AND SURFACTANT IN NEWBORNS

预测新生儿对呼吸支持和表面活性剂的需求

• 批准号: 7717904
• 负责人: WILLIAM RHINE
• 金额: $ 0.15万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717904
• 关键词: Birth; Birth Place; Birth Weight; Caring; Chronic lung disease; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consensus; Continuous Positive Airway Pressure; Devices; Enrollment; Exhalation; Funding; Grant; Guidelines; Infant; Institution; Judgment; Lead; Measurement; Mechanical Ventilators; Mechanical ventilation; Newborn Infant; Observational Study; Outcome; Patients; Physiological; Premature Infant; Research; Research Personnel; Resources; Respiratory distress; Source; Steroids; Suggestion; Trauma; United States National Institutes of Health; improved; nCPAP Ventilation; prospective; pulmonary function; respiratory; surfactant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increased use of antenatal steroids, surfactant, along with mechanical ventilation, has improved outcomes for premature infants. However, the possible overuse of mechanical ventilators may lead to trauma and chronic lung disease. There is some suggestion that some premature infants may have better outcomes if not intubated at birth, but placed on nasal continuous positive airway pressure (CPAP). At present, there are no consensus guidelines on which infants should be placed on CPAP at birth or intubated. A physiologic measurement, such as spontaneous exhaled volume, may be able to provide guidance in treatment course for newborns with respiratory distress. The aim of this study is to determine if a commercial portable pulmonary function measurement device can be used to predict the need for respiratory support and surfactant soon after birth. This will be a prospective, observational study. The measurements will not be revealed to the clinical team, who will use their judgment in deciding the patient's course of care. Outcomes will include degree of respiratory support and surfactant therapy. We plan to enroll approximately 100 patients, 50 below 1500 grams birth weight.

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