ASTHMA CONTROL EVALUATION (ACE): WEIGHT STUDY

哮喘控制评估 (ACE)：体重研究

• 批准号: 7606287
• 负责人: GEORGE T O'CONNOR
• 金额: $ 1.08万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606287
• 关键词: Acute; Adolescent; Asthma; Biolectric Impedance; Biological Markers; Blood; Blood specimen; Body fat; Body measure procedure; Bone Density; Child; Computer Retrieval of Information on Scientific Projects Database; Diet; Dual-Energy X-Ray Absorptiometry; Evaluation; Fatty acid glycerol esters; Frequencies; Funding; Grant; Health Status; Healthcare; Inflammation; Inflammatory; Institution; Interview; Leptin; Measurement; Measures; Morbidity - disease rate; Obesity; Observational Study; Participant; Patients; Physical activity; Protocols documentation; Research; Research Personnel; Research Subjects; Resources; Risk Factors; Source; Symptoms; Testing; United States National Institutes of Health; Weight; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mounting evidence points to obesity as a risk factor for asthma, but little is known about the effects of obesity on the health status of patients with asthma. To understand the relationship between obesity and asthma, it is important to measure both the percent of body fat and the fat distribution. It is also important to measure blood levels of substances such as leptin that are related to obesity and inflammation. The ACE Weight Study is an observational study of the relationship of obesity, percent body fat, fat distribution, and blood biomarkers to asthma morbidity among children and adolescents with asthma participating in the ACE study. The ACE participants will be interviewed regarding their physical activity and diet. Bioelectrical impedance analysis (a measure of percent body fat and regional body fat) and Dual Energy X-ray Absorptiometry (a routine test for bone density that also measures body fat) will be performed. A blood sample will be collected for measurement of inflammatory markers. These activities will be performed once. These measurements will be studied in relation to measures of asthma morbidity including symptom frequency, asthma exacerbation frequency, acute health care utlilization, and pulmonary function. Research subjects participating in the ACE study, protocol H23758 will be invited to participate in this ancillary weight study that was added to the ACE protocol in October 2005.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 越来越多的证据表明肥胖是哮喘的危险因素，但人们对肥胖对哮喘患者健康状况的影响知之甚少。要了解肥胖与哮喘之间的关系，测量身体脂肪百分比和脂肪分布非常重要。测量与肥胖和炎症相关的物质（例如瘦素）的血液水平也很重要。 ACE 体重研究是一项观察性研究，研究参与 ACE 研究的哮喘儿童和青少年的肥胖、体脂百分比、脂肪分布和血液生物标志物与哮喘发病率的关系。 ACE 参与者将接受有关身体活动和饮食的采访。将进行生物电阻抗分析（身体脂肪百分比和局部身体脂肪的测量）和双能 X 射线吸收测定法（骨密度的常规测试，也可测量身体脂肪）。将收集血样用于测量炎症标记物。这些活动将执行一次。这些测量结果将与哮喘发病率的测量相关联进行研究，包括症状频率、哮喘恶化频率、急性医疗保健利用和肺功能。 参与 ACE 研究协议 H23758 的研究对象将被邀请参加这项于 2005 年 10 月添加到 ACE 协议中的辅助体重研究。