URBAN ENVIRONMENTAL & CHILDHOOD ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。URECA研究将是一项为期三年的纵向前瞻性研究，从出生开始，研究城市儿童哮喘和过敏的环境和遗传风险因素。我们假设：1)市中心的环境因素对免疫系统的发育产生不利影响，从而在3岁时促进细胞因子失调、过敏和反复喘息；2)患有病毒性下呼吸道感染并在3岁时出现细胞因子失调的儿童在6岁时患哮喘的风险增加。父母有过敏性疾病或哮喘阳性病史的家庭将在出生前登记。母亲的压力和其他环境暴露将在产前进行评估。从出生开始并持续到生命的头三年，儿童将接受血细胞细胞因子反应的纵向评估，以及可能影响细胞因子反应发展的出生后环境影响(感染、过敏原和微生物暴露、压力、室内污染物)以及过敏和哮喘的临床表现(反复喘息)。最后，将从研究参与者及其母亲那里获得DNA，以评估与观察到的免疫发育模式的遗传相关性，因为它们与喘息性疾病和哮喘有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The URECA study will be a longitudinal prospective study over a three-year time period, beginning at birth, of the environmental and genetic risk factors for asthma and allergy in urban children. We hypothesize that 1) environmental factors in the inner city adversely influence the development of the immune system to promote cytokine dysregulation, allergy, and recurrent wheezing by age three years and that 2) children who have had a viral lower respiratory infection and have developed cytokine dysregulation by age three years are at increased risk for the development of asthma by age six years. Families with a positive parental history of allergic diseases or asthma will be enrolled prior to birth. Maternal stress and other environmental exposures will be assessed prenatally. Beginning at birth and continuing for the first three years of life, the children will be evaluated longitudinally for blood cell cytokine responses, and for postnatal environmental influences (infections, allergen and microbial exposure, stress, indoor pollutants) that could affect the development of cytokine responses, and for clinical manifestations of allergy and asthma (recurrent wheeze). Finally, DNA will be obtained from study participants and their mothers to evaluate genetic correlates to the observed patterns of immune development as they relate to wheezing diseases and asthma.