MCT OIL FOR ENHANCEMENT OF WEIGHT LOSS AND GLYCEMIC CONTROL IN OBESE DIABETIC PT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 2型糖尿病是与肥胖，特别是中腹部肥胖相关的几种共病之一。已经证明，适度的体重减轻（总体重的5-10%）可以改善2型糖尿病患者的血糖控制;然而，肥胖患者通常很难通过行为改变、饮食控制和锻炼来减轻体重并维持体重减轻。对于BMI 27 kg/m2且既往减肥尝试失败的糖尿病患者，可考虑特殊配方饮食和/或药物治疗。 中链甘油三酯（MCT）含有6-12个碳链长度的脂肪酸，是牛奶、椰子油和棕榈仁油的天然成分。先前的研究表明，在体内和体外，MCT衍生的中链脂肪酸（MCFA）的氧化程度高于脂肪储存（1，2）。给动物喂食MCT导致脂肪细胞数量减少和脂肪细胞尺寸变小（3）。此外，我们最近的研究结果表明，MCFA抑制前脂肪细胞分化为脂肪细胞，也下调成熟脂肪细胞中的成脂基因。总之，这些结果表明，包括MCT的饮食可能对体重控制有用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes mellitus is one of several co-morbid conditions associated with obesity, particularly central abdominal obesity. It has been demonstrated that modest weight loss (5-10% of total body weight) improves glycemic control in type 2 diabetic patients; however, obese patients usually have extreme difficulty in losing weight and maintaining that weight loss with behavioral modification, diet control, and exercise. Special formula diets and/or pharmacotherapy are considered in diabetic patients with a BMI27 kg/m2 who have previously failed in weight reduction attempts. Medium chain triglycerides (MCT) that contain fatty acids with 6-12 carbon chain lengths are natural components of milk, coconut oil and palm kernel oils. Previous studies showed that MCT derived medium chain fatty acids (MCFA) are more oxidized than stored as fat both in vivo and in vitro (1,2). Feeding MCT to animals resulted in reduced fat cell numbers and smaller fat cell sizes (3). Moreover, our recent findings showed that MCFAs inhibit preadipocyte differentiation into fat cells and also down-regulate adipogenic genes in mature adiocytes. Together, these results suggest that a diet including MCT could potentially be useful for weight control.