ACUTE HIV INFECTION AND EARLY DISEASE RESEARCH PROGRAM (AIEDRP)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一数据库方案将建立参与HIV-1发病机制研究、临床试验中评估治疗策略的研究以及选择推迟治疗但同意遵循该方案的受试者的HIV-1感染者队列。登记的受试者将根据急性或最近感染艾滋病毒-1的情况在数据库中进行分层。以明确的方式收集预期数据将使跨方案分析能够解决与急性或最近的艾滋病毒-1感染的发病机制和治疗有关的具体的长期科学问题。研究对象将完成预定的访问从注册时间到初步分析的时间。评估将包括病史、人口学、病毒学和免疫学实验室测试、为未来艾滋病毒研究储存的样本，以及治疗依从性问卷。目前，预计将有2200名科目报名。接近招生结束时注册的科目将被跟踪至少两年，而之前注册的科目可能会被跟踪14年以上。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This database protocol will establish a cohort of HIV-1-infected individuals who are participating in studies of HIV-1 pathogenesis, studies evaluating therapeutic strategies in clinical trials, and of subjects who choose to defer therapy but agree to be followed in this protocol. Enrolled subjects will be stratified in the database with regard to acute or recent HIV-1 infection. The collection of prospective data in a defined manner will allow cross-protocol analyses to address specific long-term scientific questions related to the pathogenesis and treatment of acute or recent HIV-1 infection. Study subjects will complete scheduled visits from the time of enrollment up until the time of primary analyses. Evaluations will include medical history, demographics, virology and immunology laboratory testing, stored samples for future HIV research, and treatment adherence questionnaires. Currently, 2200 subjects are expected to enroll. Subjects who enroll near the enrollment completion will be followed for a minimum of two years, while previously enrolled subjects may be followed for more than 14 years.