ACUTE HIV INFECTION AND EARLY DISEASE RESEARCH PROGRAM (AIEDRP)

急性艾滋病毒感染和早期疾病研究计划 (AIEDRP)

• 批准号: 7717555
• 负责人: MITCHELL J GOLDMAN
• 金额: $ 0.05万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717555
• 关键词: Acute; Address; Adherence; Clinical Trials; Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Disease; Enrollment; Evaluation; Funding; Future; Grant; HIV; HIV-1; Immunology; Individual; Infection; Institution; Laboratories; Medical History; Pathogenesis; Protocols documentation; Questionnaires; Research; Research Personnel; Resources; Sampling; Schedule; Source; Study Subject; Testing; Therapeutic; Time; United States National Institutes of Health; Visit; cohort; demographics; programs; prospective; virology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This database protocol will establish a cohort of HIV-1-infected individuals who are participating in studies of HIV-1 pathogenesis, studies evaluating therapeutic strategies in clinical trials, and of subjects who choose to defer therapy but agree to be followed in this protocol. Enrolled subjects will be stratified in the database with regard to acute or recent HIV-1 infection. The collection of prospective data in a defined manner will allow cross-protocol analyses to address specific long-term scientific questions related to the pathogenesis and treatment of acute or recent HIV-1 infection. Study subjects will complete scheduled visits from the time of enrollment up until the time of primary analyses. Evaluations will include medical history, demographics, virology and immunology laboratory testing, stored samples for future HIV research, and treatment adherence questionnaires. Currently, 2200 subjects are expected to enroll. Subjects who enroll near the enrollment completion will be followed for a minimum of two years, while previously enrolled subjects may be followed for more than 14 years.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本数据库方案将建立一个参与HIV-1发病机制研究、临床试验中评价治疗策略研究的HIV-1感染者队列，以及选择推迟治疗但同意接受本方案随访的受试者队列。入组受试者将在数据库中根据急性或近期HIV-1感染进行分层。以明确的方式收集前瞻性数据将允许跨方案分析，以解决与急性或近期HIV-1感染的发病机制和治疗相关的特定长期科学问题。 研究受试者将完成从入组至主要分析的计划访视。评估将包括病史、人口统计学、病毒学和免疫学实验室检测、为未来HIV研究储存的样本以及治疗依从性问卷。 目前，预计入组2200例受试者。 在入组完成时入组的受试者将接受至少2年的随访，而之前入组的受试者可接受超过14年的随访。