HIGH-FREQUENCY SOUNDS WHEN INSPIRATORY EFFORT IS HIGH IN OBSTRUCTIVE SDB

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 根据我们的观察，患有SDB的儿童和成人在睡眠时会发出高音吸气声音(频率在3到10 kHz之间)。我们认为这些声音是由于睡眠时上呼吸道狭窄所致，它们的出现与SDB有关。因此，我们提出了一个关于产生高频声音的机制的机械论假说。具体地说，我们假设患有阻塞性睡眠障碍呼吸(OSDB)的人只有在吸气努力较高时才会发出高频声音，如食道压力所测量的那样。 我们将与SDB一起研究科目。将对所有参与者进行标准的多导睡眠图睡眠研究，并测量食道压力。我们将用悬挂在床上的麦克风来录音。 我们将使用方差分析和协方差回归模型来分析数据。将在受试者之间和受试者内部进行比较。 这项研究的结果将使我们能够确定产生高频声音的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. According to our observations, children and adults with SDB make high-pitched inspiratory sounds (between 3 and 10 kHz in frequency) during sleep. We believe that these sounds are due to narrowing of the upper airway during sleep and their occurrence is associated with SDB. As such, we propose a mechanistic hypothesis about the mechansim that produces high frequency sounds. Specifically, we hypothesize that people with obstructive sleep disordered breathing (OSDB) generate high-frequency sounds only when inspiratory effort is high as measured by esophageal pressure. We will study subjects with SDB. A standard polysomnographic sleep study with the addition of measurement of esophageal pressure will be done to all participants. We will record sounds with a microphone suspended over the bed. We will use analysis of variance and covariance regression models to analyze the data. Comparisons between and within the subjects will be done. The results of this study will allow us to determine the mechanism responsible for generation of high frequency sounds.