HIGH-FREQUENCY SOUNDS WHEN INSPIRATORY EFFORT IS HIGH IN OBSTRUCTIVE SDB

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 根据我们的观察，患有SDB的儿童和成人在睡眠期间会发出高音调的吸气声（频率在3到10 kHz之间）。我们认为这些声音是由于睡眠时上呼吸道变窄引起的，它们的发生与SDB有关。 因此，我们提出了一个关于产生高频声音的机制的机械假说。 具体来说，我们假设阻塞性睡眠呼吸障碍（OSDB）的人只有在通过食管压力测量的吸气努力很高时才会产生高频声音。 我们将与SDB一起学习科目。 将对所有参与者进行标准的多导睡眠图睡眠研究，并增加食管压力测量。 我们将用悬挂在床上方的麦克风记录声音。 我们将使用方差分析和协方差回归模型来分析数据。将进行受试者之间和受试者内部的比较。 这项研究的结果将使我们能够确定负责产生高频声音的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. According to our observations, children and adults with SDB make high-pitched inspiratory sounds (between 3 and 10 kHz in frequency) during sleep. We believe that these sounds are due to narrowing of the upper airway during sleep and their occurrence is associated with SDB. As such, we propose a mechanistic hypothesis about the mechansim that produces high frequency sounds. Specifically, we hypothesize that people with obstructive sleep disordered breathing (OSDB) generate high-frequency sounds only when inspiratory effort is high as measured by esophageal pressure. We will study subjects with SDB. A standard polysomnographic sleep study with the addition of measurement of esophageal pressure will be done to all participants. We will record sounds with a microphone suspended over the bed. We will use analysis of variance and covariance regression models to analyze the data. Comparisons between and within the subjects will be done. The results of this study will allow us to determine the mechanism responsible for generation of high frequency sounds.