GENETIC LINK BETWEEN CD36 MUTATIONS AND SUSCEPTIBILITY

CD36 突变与易感性之间的遗传联系

• 批准号: 7606859
• 负责人: PHILIP George ZAGER
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606859
• 关键词: Adipocytes; African American; Albuminuria; American Indians; Asians; Blood Platelets; CD36 gene; Computer Retrieval of Information on Scientific Projects Database; Fatty Acids; Funding; Genetic; Genotype; Grant; Hispanics; Institution; Insulin Resistance; Link; Lipids; Measures; Muscle Fibers; Mutation; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pattern; Phenotype; Predisposition; Purpose; Research; Research Personnel; Resources; SR-BI receptor; Skeletal Muscle; Source; United States National Institutes of Health; glucose tolerance; impaired glucose tolerance; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to: (1) Identify American Indians, Hispanics, Whites, African Americans and Asians with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM); (2) Determine the distributions of CD36 genotypes and describe the CD36 associated phenotypes; (3) Measure CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle; (4) Determine the relationships between fatty acid clearance and CD36 genotypes and other CD36 phenotypes; and (5) Determine if obesity patterns, glucose tolerance, insulin resistance indexes, lipid profile, and albuminuria are associated with CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle cells.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是：（1）确定美国印第安人、西班牙人、白人、非洲裔美国人和亚洲人中糖耐量正常、糖耐量受损和2型糖尿病（T2 DM）;（2）确定CD 36基因型分布并描述CD 36相关表型;（3）测定血小板、脂肪细胞和骨骼肌中CD 36 mRNA水平和CD 36蛋白水平;（4）确定脂肪酸清除率与CD 36基因型和其他CD 36表型的关系;和（5）确定肥胖模式、葡萄糖耐量、胰岛素抵抗指数、脂质谱和白蛋白尿是否与血小板、脂肪细胞和骨骼肌细胞中的CD 36 m-RNA水平和CD 36蛋白水平相关。