GENETIC LINK BETWEEN CD36 MUTATIONS AND SUSCEPTIBILITY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是：（1）确定美国印第安人、西班牙人、白人、非洲裔美国人和亚洲人中糖耐量正常、糖耐量受损和2型糖尿病（T2 DM）;（2）确定CD 36基因型分布并描述CD 36相关表型;（3）测定血小板、脂肪细胞和骨骼肌中CD 36 mRNA水平和CD 36蛋白水平;（4）确定脂肪酸清除率与CD 36基因型和其他CD 36表型的关系;和（5）确定肥胖模式、葡萄糖耐量、胰岛素抵抗指数、脂质谱和白蛋白尿是否与血小板、脂肪细胞和骨骼肌细胞中的CD 36 m-RNA水平和CD 36蛋白水平相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to: (1) Identify American Indians, Hispanics, Whites, African Americans and Asians with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM); (2) Determine the distributions of CD36 genotypes and describe the CD36 associated phenotypes; (3) Measure CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle; (4) Determine the relationships between fatty acid clearance and CD36 genotypes and other CD36 phenotypes; and (5) Determine if obesity patterns, glucose tolerance, insulin resistance indexes, lipid profile, and albuminuria are associated with CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle cells.