GENETIC LINK BETWEEN CD36 MUTATIONS AND SUSCEPTIBILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是：(1)确定糖耐量正常、糖耐量受损和2型糖尿病(T2 DM)的美洲印第安人、拉美裔、白人、非裔美国人和亚洲人；(2)确定CD36基因的分布并描述CD36相关表型；(3)测定血小板、脂肪细胞和骨骼肌中CD36 m-RNA水平和CD36蛋白水平；(4)确定脂肪酸清除与CD36基因和其他CD36表型的关系；以及(5)确定肥胖模式、糖耐量、胰岛素抵抗指数、血脂和蛋白尿是否与血小板、脂肪细胞和骨骼肌细胞中的CD36 m-RNA水平和CD36蛋白水平相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to: (1) Identify American Indians, Hispanics, Whites, African Americans and Asians with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM); (2) Determine the distributions of CD36 genotypes and describe the CD36 associated phenotypes; (3) Measure CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle; (4) Determine the relationships between fatty acid clearance and CD36 genotypes and other CD36 phenotypes; and (5) Determine if obesity patterns, glucose tolerance, insulin resistance indexes, lipid profile, and albuminuria are associated with CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle cells.