GENETICS OF KIDNEY DISEASE IN ZUNI INDIANS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是解决以下问题： 1.在祖尼族印度人中，是否存在增加或减少糖尿病和/或非糖尿病肾病风险的基因？ 2.是否有基因对血压、尿蛋白、尿血和肾功能有很大的影响？这些基因在糖尿病和非糖尿病的祖尼印第安人之间有区别吗？ 3.是否有基因对其他性状有很大的影响，[例如肥胖，高血脂水平，高血压]？这些基因在糖尿病和非糖尿病的祖尼印第安人之间有区别吗？ 4.是否存在影响肾脏疾病风险的重要遗传-环境相互作用？如果是这样的话，这些相互作用在糖尿病和非糖尿病祖尼印第安人之间有什么不同吗？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to address the following questions: 1.Are there genes that increase or decrease the risk of diabetic and/or non-diabetic kidney disease among the Zuni Indian population? 2.Are there genes that have a large effect on blood pressure, urine protein, blood in urine, and kidney function? Do these genes differ between diabetic and non-diabetic Zuni Indians? 3.Are there genes that have a large effect on other traits, [e.g. obesity, high blood lipid levels, high blood pressure]? Do these genes differ between diabetic and non-diabetic Zuni Indians? 4.Are there important genetic-environmental interactions that affect the risk of kidney disease? If so, do these interactions differ between diabetic and non-diabetic Zuni Indians?