GENETICS OF KIDNEY DISEASE IN ZUNI INDIANS

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是解决以下问题： 1.是否有基因会增加或降低祖尼印第安人患糖尿病和/或非糖尿病肾病的风险？ 2.是否有对血压、尿蛋白、尿中血、肾功能影响较大的基因？糖尿病祖尼印第安人与非糖尿病祖尼印第安人的这些基因有何不同？ 3.是否有对其他性状有很大影响的基因，[例如肥胖、高血脂、高血压]？糖尿病祖尼印第安人与非糖尿病祖尼印第安人的这些基因有何不同？ 4.是否存在影响肾脏疾病风险的重要遗传-环境相互作用？如果是这样，糖尿病祖尼印第安人与非糖尿病祖尼印第安人之间的这些相互作用是否有所不同？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to address the following questions: 1.Are there genes that increase or decrease the risk of diabetic and/or non-diabetic kidney disease among the Zuni Indian population? 2.Are there genes that have a large effect on blood pressure, urine protein, blood in urine, and kidney function? Do these genes differ between diabetic and non-diabetic Zuni Indians? 3.Are there genes that have a large effect on other traits, [e.g. obesity, high blood lipid levels, high blood pressure]? Do these genes differ between diabetic and non-diabetic Zuni Indians? 4.Are there important genetic-environmental interactions that affect the risk of kidney disease? If so, do these interactions differ between diabetic and non-diabetic Zuni Indians?