GENETIC LINK BETWEEN CD36 MUTATIONS AND SUSCEPTIBILITY

CD36 突变与易感性之间的遗传联系

• 批准号: 7716561
• 负责人: PHILIP George ZAGER
• 金额: $ 0.58万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716561
• 关键词: Adipocytes; African American; Albuminuria; American Indians; Asians; Blood Platelets; CD36 gene; Computer Retrieval of Information on Scientific Projects Database; Fatty Acids; Funding; Genetic; Genotype; Grant; Hispanics; Institution; Insulin Resistance; Link; Lipids; Measures; Muscle Fibers; Mutation; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pattern; Phenotype; Predisposition; Purpose; Research; Research Personnel; Resources; SR-BI receptor; Skeletal Muscle; Source; United States National Institutes of Health; glucose tolerance; impaired glucose tolerance; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to: (1) Identify American Indians, Hispanics, Whites, African Americans and Asians with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM); (2) Determine the distributions of CD36 genotypes and describe the CD36 associated phenotypes; (3) Measure CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle; (4) Determine the relationships between fatty acid clearance and CD36 genotypes and other CD36 phenotypes; and (5) Determine if obesity patterns, glucose tolerance, insulin resistance indexes, lipid profile, and albuminuria are associated with CD36 m-RNA levels and CD36 protein levels in platelets, adipocytes, and skeletal muscle cells.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是： (1) 识别糖耐量正常、糖耐量受损和 2 型糖尿病 (T2DM) 的美洲印第安人、西班牙裔、白人、非裔美国人和亚洲人； (2)确定CD36基因型的分布并描述CD36相关表型； (3) 测定血小板、脂肪细胞、骨骼肌中CD36 mRNA水平和CD36蛋白水平； (4)确定脂肪酸清除率与CD36基因型及其他CD36表型之间的关系； (5)确定肥胖模式、葡萄糖耐量、胰岛素抵抗指数、血脂和蛋白尿是否与血小板、脂肪细胞和骨骼肌细胞中的CD36 mRNA水平和CD36蛋白水平相关。