A PHASE III DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL OF LONG TERM THERAPY OF

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：检测单纯疱疹病毒性脑炎(HSE)标准IV抗病毒治疗后长期口服抗病毒治疗对改善远期疗效的效果。 1-长期口服万乃洛韦能改善HSE的预后吗？ 长期服用大剂量万乃洛韦治疗HSE的药代动力学如何？ 容量磁共振成像显示的HSE患者的神经心理结果与中枢神经系统HSV数量之间是否存在相关性？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test efficacy of prolonged oral antiviral therapy in improving long term outcome of herpes simplex encephalitis (HSE), following standard IV antiviral treatment. 1- Does long term oral valacyclovir improve outcome in HSE? 2- What are the pharmacokinetics of high dose oral valacyclovir used long term for HSE? 3- Is there a correlation between neuropsychologic outcome following HSE with volumetric MRI and HSV quantity in the CNS?