CLINICAL TRIAL: INVESTIGATION OF THE NATURAL HISTORY OF WEST NILE VIRUS INFECTIO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 北卡罗来纳大学的医学和神经科正在对一种新出现的病毒性疾病--西尼罗河病毒--做出反应，参与由NIH赞助的描述疾病自然病史的试验，并测试一种新的治疗方法。 拟议的研究旨在1)测试WN免疫球蛋白在高危人群中预防或消除严重WN疾病的安全性和有效性(I/II期)，以及2)确定WN感染的自然历史。 拟议的研究将整合基础科学和临床科学。病毒特性和免疫反应将在阿拉巴马州大学和新墨西哥州大学进行。临床研究包括观察性研究和I/II期治疗试验。教育方面包括指导研究员、住院医生和初级教职员工，他们将作为试验的新调查人员参与。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The divisions of Medicine and Neurology at UNM are responding to an emerging viral disease, West Nile Virus, by participating in NIH sponsored trials describing the natural history of illness and testing a new therapy. The proposed studies aim to 1) test safety and efficacy (phase I/II) of WN immune globulin in preventing or abrogating severe WN disease in high risk population groups, and 2) to define the natural history of WN infection. The proposed studies will integrate basic science and clinicalscience. Virus characterization and immune responses will take place at U. Alabama and at UNM. Clinical studies include an observational study and a Phase I/II treatment trial. Educational aspects include mentoring of fellows, residents and junior faculty who will be participating as new investigators on the trials.