CLINICAL TRIAL: INVESTIGATION OF THE NATURAL HISTORY OF WEST NILE VIRUS INFECTIO

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 新墨西哥州医学和神经病学部门正在通过参与 NIH 赞助的描述疾病自然史的试验并测试新疗法来应对一种新出现的病毒性疾病——西尼罗河病毒。 拟议的研究旨在 1) 测试 WN 免疫球蛋白在预防或消除高危人群中严重 WN 疾病方面的安全性和有效性（I/II 期），2) 确定 WN 感染的自然史。 拟议的研究将整合基础科学和临床科学。 病毒表征和免疫反应将在阿拉巴马州和新墨西哥大学进行。临床研究包括观察性研究和 I/II 期治疗试验。 教育方面包括对将作为新研究人员参与试验的研究员、住院医师和初级教员进行指导。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The divisions of Medicine and Neurology at UNM are responding to an emerging viral disease, West Nile Virus, by participating in NIH sponsored trials describing the natural history of illness and testing a new therapy. The proposed studies aim to 1) test safety and efficacy (phase I/II) of WN immune globulin in preventing or abrogating severe WN disease in high risk population groups, and 2) to define the natural history of WN infection. The proposed studies will integrate basic science and clinicalscience. Virus characterization and immune responses will take place at U. Alabama and at UNM. Clinical studies include an observational study and a Phase I/II treatment trial. Educational aspects include mentoring of fellows, residents and junior faculty who will be participating as new investigators on the trials.