CLINICAL TRIAL: A PHASE III DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL OF LONG TERM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 测试标准IV抗病毒治疗后延长口服抗病毒治疗对改善单纯疱疹病毒性脑炎（HSE）长期结局的疗效。 1-长期口服伐昔洛韦能改善HSE的预后吗？ 2-长期口服大剂量伐昔洛韦治疗HSE的药代动力学是什么？ 3-HSE后的神经心理学结果与体积MRI和CNS中HSV数量之间是否存在相关性？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test efficacy of prolonged oral antiviral therapy in improving long term outcome of herpes simplex encephalitis (HSE), following standard IV antiviral treatment. 1- Does long term oral valacyclovir improve outcome in HSE? 2- What are the pharmacokinetics of high dose oral valacyclovir used long term for HSE? 3- Is there a correlation between neuropsychologic outcome following HSE with volumetric MRI and HSV quantity in the CNS?