CLINICAL TRIAL: A PHASE III DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL OF LONG TERM

临床试验：III 期双盲、安慰剂对照长期试验

• 批准号: 7716573
• 负责人: Diane E Goade
• 金额: $ 0.48万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716573
• 关键词: Antiviral Agents; Antiviral Therapy; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Dose; Drug Kinetics; Funding; Grant; Herpes encephalitis; Institution; Magnetic Resonance Imaging; Neuropsychology; Oral; Outcome; Phase; Research; Research Personnel; Resources; Simplexvirus; Source; Standards of Weights and Measures; Testing; United States National Institutes of Health; double-blind placebo controlled trial; improved; valacyclovir

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test efficacy of prolonged oral antiviral therapy in improving long term outcome of herpes simplex encephalitis (HSE), following standard IV antiviral treatment. 1- Does long term oral valacyclovir improve outcome in HSE? 2- What are the pharmacokinetics of high dose oral valacyclovir used long term for HSE? 3- Is there a correlation between neuropsychologic outcome following HSE with volumetric MRI and HSV quantity in the CNS?

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