THE EFFECT OF ETHANOL ON OVERNIGHT GLUCOSE REGULATION IN TYPE 2 DIABETES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moderate doses of ethanol cause overnight hypoglycemic vulnerability in elder, insulin requiring patients with type 2 diabetes by interfering with one or several of the physiologic processes critical to the defense against hypoglycemia. The alteration investigated in this study is exacerbation of the deficient counterregulatory response to hypoglycemia that occurs normally during sleep. To compare the overnight effects of moderate doses of both orally and intravenously administered ethanol or placebo on counterregulatory hormone release and recovery from insulin-induced hypoglycemia during sleep among 12 elder healthy and 12 elder subjects with insulin requiring type 2 diabetes.