THE EFFECT OF ETHANOL ON OVERNIGHT GLUCOSE REGULATION IN TYPE 2 DIABETES

乙醇对 2 型糖尿病患者夜间血糖调节的影响

• 批准号: 8166594
• 负责人: MARK R BURGE
• 金额: $ 2.19万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166594
• 关键词: Alcohols; Blood Glucose; Computer Retrieval of Information on Scientific Projects Database; Dose; Elderly; Ethanol; Funding; Grant; Hypoglycemia; Institution; Insulin; Non-Insulin-Dependent Diabetes Mellitus; Oral; Patients; Placebos; Research; Research Personnel; Resources; Risk; Sleep; Source; System; United States National Institutes of Health; alcohol effect; blood glucose regulation; diabetic patient; non-diabetic; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moderate doses of alcohol may cause a risk of overnight hypoglycemia [i.e.- low blood sugars] in elderly, type 2 diabetic patients who use insulin because alcohol may interfere with the body's defense systems against hypoglycemia. Other studies suggest that alcohol is more disruptive to the defense against hypoglycemia in people with type 2 diabetes than in nondiabetic patients. This study aims to establish whether or not this effect is worsened by sleep. This study is looking at the body's response to low blood sugars that may occur overnight during sleep. It compares the overnight effects of moderate doses of ethanol or placebo [both oral and IV] during sleep among 12 healthy elderly and 12 elderly subjects with insulin dependent type 2 diabetes.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在使用胰岛素的老年2型糖尿病患者中，中等剂量的酒精可能会导致夜间低血糖[即低血糖]的风险，因为酒精可能会干扰人体抵御低血糖的防御系统。其他研究表明，与非糖尿病患者相比，酒精对2型糖尿病患者抵抗低血糖的破坏更大。这项研究旨在确定这种影响是否会因睡眠而恶化。 这项研究关注的是身体对睡眠中可能出现的夜间低血糖的反应。它比较了12名健康老年人和12名患有胰岛素依赖型2型糖尿病的老年受试者在睡眠期间服用中等剂量乙醇或安慰剂[包括口服和静脉注射]的过夜效果。