DISCOVERY AND ASSESSMENT OF GENETIC AND ENVIRONMENT

遗传和环境的发现和评估

• 批准号: 7607597
• 负责人: Petr Protiva
• 金额: $ 0.37万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607597
• 关键词: Affect; Biliary; Characteristics; Chronic Disease; Clinical; Computer Retrieval of Information on Scientific Projects Database; Contracts; DNA; Databases; Development; Disease; Environment; Funding; Future; Genetic; Genetic Polymorphism; Genotype; Grant; Institution; Outcome; Pancreatic Diseases; Patients; Phenotype; Research; Research Personnel; Resources; Severities; Source; Specimen; Tissues; United States National Institutes of Health; acquired factor; base; design; liver biopsy; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Host genetic, acquired factors and environmental influences affect the development, severity, progression, and outcome of many chronic diseases, including hepato-biliary-pancreatic diseases. To facilitate the discovery of new genetic factors that influence development or progression of chronic diseases, we need to develop tissue and Deoxyribonucleic acid (DNA) banks and correlate results of polymorphisms and mutational analyses (genotypes) with patient and clinical characteristics (phenotypes). To provide the necessary databases for such studies, we need to build-up clinical databases and tissue and DNA banks. This project is designed to accomplish this for patients with hepato-biliary diseases seen at UConn who will be undergoing liver biopsies for reasons unrelated to this study. We expect the database and specimen repository thus developed will allow us to perform important and informative new analyses, and will form the basis for new grant and contract applications in the future. It will serve as a paradigm for other studies in other diseases and disorders. The potential is great for studies of the kind. We need support from the GCRC cores in order to get these initiatives off to a successful start.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 宿主遗传、获得性因素和环境影响影响许多慢性疾病的发展、严重程度、进展和结果，包括肝胆胰腺疾病。为了促进发现影响慢性疾病发展或进展的新的遗传因素，我们需要建立组织和脱氧核糖核酸(DNA)库，并将多态和突变分析(基因类型)的结果与患者和临床特征(表型)相关联。为了为这类研究提供必要的数据库，我们需要建立临床数据库和组织和DNA库。该项目旨在为康涅狄格州大学的肝胆疾病患者实现这一点，这些患者将因与本研究无关的原因接受肝脏活检。我们预计，这样开发的数据库和标本储存库将使我们能够进行重要的和信息丰富的新分析，并将成为未来新的赠款和合同申请的基础。它将为其他疾病和障碍的其他研究提供范例。这类研究的潜力是巨大的。我们需要GCRC核心部门的支持，才能使这些举措有一个成功的开端。