FIRHAD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 尽管开展了旨在减少和消除健康和疾病方面种族/族裔差异的研究活动，但巨大的差异仍然存在。研究人员通常将这些差异归因于饮食、吸烟和糟糕的医疗保健。虽然这些因素肯定有助于种族/民族差异的健康结果和疾病，有越来越多的文献表明，除了这些因素的健康结果也决定了心理社会，心理神经免疫，个性，应对（积极和消极），情感，人际关系，宗教和社会人口变量的动态相互作用。本研究项目将在预测肾脏健康和疾病的有效性的背景下，研究疾病和健康结果的生物心理社会模型的有效性。为了实现这一目标，将对一系列神经心理学、人格、心理生理学和心理社会学指标的表现与免疫、内分泌、肾脏和葡萄糖功能指标进行比较。本研究的参与者将包括来自华盛顿大都市区的300名（150名男性和150名女性）18岁及以上的非洲裔美国人的社区样本。这项研究还旨在审查远程保健技术作为改变导致肾功能受损的行为/生活方式的工具的效用，以及这种情况发展为肾病及其终末期的情况。这项干预研究将在本研究的第三年和第四年设计和实施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite research initiatives aimed at reducing and eliminating racial/ethnic disparities in health and disease, large disparities continue to exist. Typically researchers have attributed these disparities to diet, smoking and poor health care. While these factors certainly contribute to racial/ethnic disparities in health outcomes and disease, there is a growing literature which shows that in addition to these factors health outcomes are also determined by the dynamic interplay of psychosocial, psychoneuroimmunological, personality, coping (positive and negative), affective, interpersonal, religious, and sociodemographic variables. This research project will examine the validity of a biopsychosocial model of disease and health outcomes in the context of its efficacy inpredicting renal health and disease. To achieve this objective, performance on a battery of neuropsychological, personality, psychophysiological and pyschosocial measure will be compared to indices of immune, endocrine, renal and glucose functions. Participants in this study will include a community-based sample of 300 (150 male and 150 females) African Americans aged 18 and above from the Washington, DC, metropolitan area. this study is also designed to examine the utility of telehealth technology as a tool for modifying behaviors/lifestyles that contribute to impaired renal functions and the progression of this condition to renal disease and it end stage. This intervention study will be designed and implemented during year three and four of this study.