FIRHAD

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。尽管采取了旨在减少和消除健康和疾病方面的种族/族裔差异的研究举措，但仍然存在巨大的差异。研究人员通常将这些差异归因于饮食、吸烟和糟糕的医疗保健。虽然这些因素肯定会导致健康结果和疾病方面的种族差异，但越来越多的文献表明，除了这些因素外，健康结果还取决于社会心理、心理神经免疫学、个性、应对（积极和消极）、情感、人际、宗教和社会人口变量的动态相互作用。本研究项目将检验疾病和健康结果的生物心理社会模型在预测肾脏健康和疾病方面的有效性。为了实现这一目标，将神经心理学、人格、心理生理学和社会心理测量的表现与免疫、内分泌、肾脏和葡萄糖功能的指标进行比较。这项研究的参与者将包括一个以社区为基础的300名（150名男性和150名女性）来自华盛顿特区大都会区18岁及以上的非裔美国人样本。本研究还旨在研究远程医疗技术作为一种工具的效用，以改变导致肾功能受损的行为/生活方式，并将这种情况进展为肾脏疾病及其终末期。本干预研究将在本研究的第三年和第四年进行设计和实施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite research initiatives aimed at reducing and eliminating racial/ethnic disparities in health and disease, large disparities continue to exist. Typically researchers have attributed these disparities to diet, smoking and poor health care. While these factors certainly contribute to reacila/ethnic disparities in health outcome and disease, there is a growing literature which shows that in addition to these factors health outcomes are also determined by the dynamic interplay of psychosocial, psychoneuroimmunological, personality, coping (positive and negative), affective, interpersonal, religious, and sociodemographic variables. This research project will examine the validity of a biopsychosocial model of disease and health outcomes in the context of its efficacy in predicting renal health and disease. To achieve this objective, performance on a battery of neuropsychological, personality, and psychophysiological and psychosocial measures will be compared to indices of immune, endocrine, renal and glucose functions. Participants in this study will include a community-based sample of 300 (150 male and 150 females) african americans aged 18 and above from the washington, dc, metropolitan area. This study is also designed to examine the utility of telehealth technology as a tool for modifying behaviros/lifestyles that contribute to impaired renal functions and the progression of this condition to renal disease and its end stage. This intervention study will be designed and implemented during year three and four of this study.