DIABETES GENETICS CONSORTIUM

糖尿病遗传学联盟

• 批准号: 7607759
• 负责人: LAWRENCE M DOLAN
• 金额: $ 1.11万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607759
• 关键词: Affect; Antibodies; Appointment; Area; Blood; Blood specimen; Cell Line; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; Consent; DNA; Databases; Diabetes Mellitus; Family; Family health status; Funding; Future; Genes; Genetic Structures; Grant; Individual; Institution; Insulin-Dependent Diabetes Mellitus; Mails; Medical Genetics; Medical History; Methods; Molecular Genetics; Parents; Participant; Prevention therapy; Production; Questionnaires; Recording of previous events; Research; Research Personnel; Resources; Risk; Schedule; Siblings; Source; Telephone; Testing; United States National Institutes of Health; demographics; diabetes mellitus genetics; diabetic; interest; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) is a collaborative effort looking to undertake molecular genetic studies to identify individual genes that determine an individual's risk of or protection from type 1diabetes. The study's objectives are: 1) to obtain, study, and establish a renewable source of DNA on 3,000 families worldwide with at least 2 siblings with type 1 diabetes, their parents, and up to 2 siblings without diabetes for studies to identify genes that affect the risk for type 1 diabetes; 2) to create a database for the scientific community with clinical, genetic and medical history information that will facilitate the search for genes that make one susceptible to type 1 diabetes; 3) to provide a central DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; and 4) to evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention, and therapy in the area of type 1 diabetes. Once a family has been identified, and deemed eligible, study information is mailed and followed by phone calls to determine their interest level. If a family is interested, an appointment is scheduled. Questionnaires are completed regarding information on demographics, and family health history. The consent is discussed and signed. Blood samples are obtained from each participant. blood is collected for future diabetic testing, production of a DNA cell line, and diabetes antibodies on the siblings with diabetes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 1型糖尿病遗传学联盟（T1 DGC）是一个合作的努力，希望进行分子遗传学研究，以确定决定个人的1型糖尿病的风险或保护的个别基因。 该研究的目标是： 第一章 获取、研究和建立全世界3,000个家庭的可再生DNA来源，这些家庭至少有2个兄弟姐妹患有1型糖尿病，他们的父母和最多2个没有糖尿病的兄弟姐妹，用于研究识别影响1型糖尿病风险的基因; （二） 为科学界创建一个包含临床、遗传和病史信息的数据库，这将有助于寻找使人容易患1型糖尿病的基因; 第三章 提供一个中央DNA储存库，以便有针对性地研究1型糖尿病的遗传结构和功能;以及 四、 评估扩大研究成果的机会，以开发1型糖尿病领域的风险预测、预防和治疗方法。 一旦一个家庭被确定，并被认为是合格的，研究信息被邮寄，然后通过电话，以确定他们的兴趣水平。 如果一个家庭感兴趣，预约。 填写了关于人口统计学和家庭健康史的资料。 讨论并签署同意书。 从每个参与者身上采集血样。 收集血液用于将来的糖尿病测试、DNA细胞系的产生以及患有糖尿病的兄弟姐妹的糖尿病抗体。