SEARCH 3 Cohort Study to Assess Incidence of Acute and Chronic Diabetes-related C

SEARCH 3 队列研究评估急性和慢性糖尿病相关的 C 发病率

• 批准号: 8531693
• 负责人: LAWRENCE M DOLAN
• 金额: $ 60.02万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531693
• 关键词: SEARCH; Cohort; Study; Assess; Incidence

Project Summary SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other socio-cultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. In collaboration with the other SEARCH clinical centers, the Ohio site will collect the data described in this proposal from all eligible cases. We expect approximately 646 Ohio subjects will be eligible to participate. For Incident 2002-2005 cases, 85% of the Ohio participants have returned for at least one follow-up visit, which is the highest study-wide response rate. The Ohio team also has the highest rate for completeness of laboratory core samples. For Incident 2006 cases, Ohio had 99% completeness, and 100% completeness for Incident 2008 cases. In this proposal the Ohio site will employ the same approach and techniques used in SEARCH 1 and 2 to maintain high subject retention rates. Thus, the Ohio site has a very high likelihood of meeting the recruitment goals in this proposal contributing significantly to the success of the SEARCH Cohort Study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

项目概要 SEARCH for Diabetes in Youth (SEARCH) 是一项持续进行的多中心研究，包含最大、最 美国曾对患有糖尿病的不同种族青少年进行过研究。响应 RFA-DP10-001， B 部分，即“搜索队列研究”将通过继续研究选定的对象来利用这一独特的资源。 SEARCH 参与者要实现以下目标：1) 评估以下疾病的患病率、发病率和风险因素： 慢性微血管病（视网膜病、肾病和自主神经病）的选定标志物和 糖尿病的大血管并发症（高血压、动脉硬化）； 2）评估发生率和风险 糖尿病急性并发症的因素，包括严重低血糖和糖尿病酮症酸中毒； 3） 进行死亡率监测； 4) 确定护理障碍、护理质量和 向成人护理的过渡会影响糖尿病相关的健康结果，包括生活质量。覆盖在这些 目标，我们将重点关注种族/民族和其他社会文化因素以及生化维度的影响 糖尿病类型，与糖尿病相关的健康结果。 SEARCH 队列研究将进行面对面的研究 对 2002 年或之后发生的 SEARCH 参与者事件进行研究访问，且糖尿病病程 > 5 年且 基线数据已完成（预计 n=3699）。在这项研究期间，病史、人体测量学、 将收集和分析生化、生理和调查数据。与其他人合作 俄亥俄州 SEARCH 临床中心站点将从所有符合条件的病例中收集本提案中描述的数据。 我们预计大约 646 名俄亥俄州受试者将有资格参加。对于 2002-2005 年事件案例，85% 的俄亥俄州参与者已返回至少一次随访，这是整个研究范围内反应最高的 速度。俄亥俄州团队的实验室岩心样本完整性也是最高的。 2006 年事件 案例中，俄亥俄州的完整性为 99%，2008 年事件案例的完整性为 100%。在此提案中 俄亥俄州站点将采用与搜索 1 和 2 中使用的相同方法和技术来保持高主题 保留率。因此，俄亥俄工厂很有可能实现本提案中的招聘目标 对 SEARCH 队列研究的成功做出了重大贡献。这项研究将利用规模和 研究人群的种族多样性，以确定护理过程和健康结果的差异 传统的临床糖尿病类型；美国主要种族/族裔群体；并通过采用小说 通过病理生理学维度区分传统临床糖尿病类型的方法。因此，搜索 队列研究很可能对青少年糖尿病患者的临床护理产生重大影响 美国所有主要种族群体以及国家公共卫生政策。