MECHANISMS MEDIATING CARDIOVASCULAR DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是通过研究阻塞性睡眠呼吸暂停儿童在血压控制、心脏大小和功能方面的差异，了解睡眠呼吸暂停对心脏和血压的影响。我们还在研究阻塞性睡眠呼吸暂停治疗对血压控制以及心脏大小和功能改变的影响，并与没有阻塞性睡眠呼吸暂停的儿童进行比较。 这是一项为期一年的研究，将包括一次筛查访问和四次研究访问，分别在访问1、治疗后6周、治疗后6个月和治疗后1年进行。对于符合条件的受试者，每个受试者将有3-4次过夜(取决于受试者所在的研究小组)，其中包括多导睡眠图(睡眠研究)、三次超声心动图和四次家庭24小时动态血压测试。我们的研究包括测量呼吸、血压、睡眠质量以及心脏大小和功能。 参与者是从6-13岁疑似阻塞性睡眠呼吸暂停(OSA)且仍有扁桃体或腺样体的儿童中招募的。这些儿童将与6-13岁的对照组儿童配对，这些儿童没有打呼噜或没有OSA症状，并且在过去两年内没有切除扁桃体或腺样体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to understand the effect of sleep apnea on the heart and blood pressure by studying the differences in control of blood pressure and the size and function of the heart in children with obstructive sleep apnea. We are also studying the effect of treatment of obstructive sleep apnea on these changes in blood pressure control and the size and function of the heart in comparison to children without obstructive sleep apnea. This is a one-year study that will involve a screening visit and four study visits spaced at visit 1, 6 weeks post treatment, 6 months post treatment, and 1 year post treatment. For subjects who qualify, each subject will have 3-4 overnight stays (depending on which study group the subject is placed) that includes a polysomnography (sleep study), three echocardiographs, and four home 24-hour ambulatory blood pressure tests. Our study involves measuring breathing, blood pressure, sleep quality, and heart size and function. Participants are recruited from children ages 6-13 years with suspected obstructive sleep apnea (OSA) and who still have their tonsils or adenoids. These children will be matched with a control group of children ages 6-13 who do not snore or have symptoms of OSA and who have not had their tonsils or adenoids removed within the past two years.