MECHANISMS MEDIATING CARDIOVASCULAR DISEASE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to understand the effect of sleep apnea on the heart and blood pressure by studying the differences in control of blood pressure and the size and function of the heart in children with obstructive sleep apnea. We are also studying the effect of treatment of obstructive sleep apnea on these changes in blood pressure control and the size and function of the heart in comparison to children without obstructive sleep apnea. This is a one-year study that will involve a screening visit and four study visits spaced at visit 1, 6 weeks post treatment, 6 months post treatment, and 1 year post treatment. For subjects who qualify, each subject will have 3-4 overnight stays (depending on which study group the subject is placed) that includes a polysomnography (sleep study), three echocardiographs, and four home 24-hour ambulatory blood pressure tests. Our study involves measuring breathing, blood pressure, sleep quality, and heart size and function. Participants are recruited from children ages 6-13 years with suspected obstructive sleep apnea (OSA) and who still have their tonsils or adenoids. These children will be matched with a control group of children ages 6-13 who do not snore or have symptoms of OSA and who have not had their tonsils or adenoids removed within the past two years.