VASCULAR FUNCTION IN CHILDREN WITH OSA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在探讨5~13岁睡眠呼吸阻塞综合征患儿血管顺应性和僵硬度的变化。它的目的是研究综合征的严重程度与血管功能和与动脉僵硬早期阶段相关的特定炎症介质的关系，以及它们对心血管终点(即24小时动态血压和左心室质量)的影响。这项研究还将检查血浆和扁桃体组织中炎性细胞因子水平之间的关系。我们的目标是确定儿童时期的血管风险因素，并确定儿童睡眠呼吸障碍是否代表心血管疾病的一个独立风险因素，如果识别不当，可能会追溯到成年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to investigate the changes in blood vessels compliance and stiffness in children ages 5 to 13 years with the syndrome of obstructive breathing during sleep. It is designed to examine the relationship of the severity of the syndrome to vascular functions and to specific inflammatory mediators related to early stages of arterial stiffness and their effect on cardiovascular endpoints, namely twenty-four hour ambulatory blood pressure and left ventricular mass. This study will also examine the relationship between plasma and tonsillar tissue levels of inflammatory cytokines. Our aim is to identify vascular risk factors in childhood and to determine whether sleep disordered breathing in children represents an independent risk factor for cardiovascular disease which, if left inadequately identified, could track into adult years.