EFFECT OF HEPATITIS C ON INSULIN RESISTANCE IN CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 A.具体目的/目标 一组年龄、性别、体重指数(BMI)和Tanner分期匹配的丙型肝炎病毒感染儿童和健康对照组将被研究，以评估是否： 1)丙型肝炎病毒感染与儿童胰岛素抵抗相关 2)清除丙型肝炎病毒感染可改善儿童的胰岛素抵抗 3)丙型肝炎病毒感染与较高的肿瘤坏死因子-α和较低的脂联素水平相关，而这反过来又与胰岛素抵抗有关，既有横向的也有纵向的。 通过上述目标，将检验以下假设： 1)丙型肝炎病毒感染与儿童胰岛素抵抗相关 2)清除丙型肝炎病毒感染会降低儿童的胰岛素抵抗 3)炎性脂肪因子在丙型肝炎病毒相关性胰岛素抵抗中的作用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims /Objectives A cohort of children with HCV infection and healthy controls matched for age, gender, body mass index (BMI), and Tanner stage will be studied to evaluate whether: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection improves IR in children 3) HCV infection correlates with higher TNF-alpha and lower adiponectin levels and these, in turn, correlate with IR both cross-sectionally as well as longitudinally Through the above aims, the following hypotheses will be tested: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection reduces IR in children 3) Inflammatory adipokines mediate the development of HCV-associated IR