Asian Americans & Racism: Individual and Structural Experiences (ARISE)

项目总结/摘要 毫无问题”、“永远的外国人”、“沉默的少数”、“都一样”--这些都是刻板印象， 长期以来，亚裔美国人（ASA）一直深受其害，他们通常被称为“模范少数族裔”。全美金曲奖， 然而，它包含了文化，语言，移民经历， 社会经济地位（SES）和宗教。种族主义和对ASA的歧视 于2019冠状病毒病大流行期间以新的强度重新出现。个人和地区一级 种族主义和歧视与健康方面的重大差距有关， 阿尔茨海默病及相关痴呆症（ADRD）。对ASA来说，种族主义和歧视， 个人和区域级别（例如，居住隔离;红线）可能会导致潜在的 认知健康差异;然而，ASA的这一研究领域研究不足。有限 研究表明，至少一些阿萨组的ADRD风险低于非西班牙裔 白色个体。识别潜在的保护因素（例如，家庭凝聚力）， 减少与种族主义有关的风险是一个重要的科学机会。研究报告审查了 与ASA的ADRD风险相关的多层次歧视是非常需要的，但有限。我们 亚裔美国人与种族主义：个人和结构经验（ARISE） 在NIA健康差异框架的指导下，将在以下地区建立一个多地点、多语言的队列， 加州研究多层次歧视的普遍性和影响， 1,500名中国老年人（≥65岁）ADRD相关风险的弹性资源， 韩国人和越南裔美国人。我们将利用PI Park的NIA资助的协作 AAPI研究和教育（CARE）注册处作为我们的招聘来源之一。 我们的具体目标包括：1）建立ARISE队列，以确定生命的患病率 多层次歧视的过程中的经验，老年人之间的中国，韩国， 越南裔美国人; 2）评估多层次歧视对认知的关联 总体和按阿萨亚组、性别和主要疾病列出的AD生物标志物的表现和水平 语言交流参与者次要/探索性目的：评价相关性 多层次歧视和认知能力下降之间的关系; 3）评估保护性和风险性 影响多水平辨别对认知表现和水平影响的因素 ARISE参与者中的AD生物标志物。ARISE的科学承诺是及时的， 必要COVID-19疫情暴露并加剧了反亚洲种族主义。出现 将增加我们对代表性不足和参与不足的ASA的有限理解 ADRD和老化研究。

Project Summary/Abstract Problem-free”, “perpetual foreigner”, “silent minority”, “all the same” – these are stereotypes that have long plagued Asian Americans (ASAs), often referred to as the “model minority”. ASAs, however, encompasses a diversity of cultures, languages, immigration experiences, socioeconomic status (SES), and religions. Racism and discrimination against ASAs are not new but resurfaced with new intensity during the COVID-19 pandemic. Individual and area level racism and discrimination are tied to significant health disparities that influence risk of Alzheimer’s Disease and Related Dementias (ADRD). For ASAs, racism and discrimination at the individual and area level (e.g., residential segregation; redlining) may result in potential cognitive health disparities; however, this area of research in ASAs is understudied. Limited research suggests that at least some ASA groups have lower ADRD risk than non-Hispanic White individuals. Identification of potential protective factors (e.g., family cohesion) that may mitigate racism-related risk is an important scientific opportunity. Studies examining the role of multi-level discrimination related to ASAs’ risk for ADRD are sorely needed but limited. Our proposed study, Asian Americans & Racism: Individual and Structural Experiences (ARISE), guided by the NIA health disparities framework, will develop a multi-site, multi-lingual cohort in California to study the prevalence as well as the impact of multi-level discrimination and resilience resources on associated risk for ADRD among 1,500 older (≥65 years old) Chinese, Korean, and Vietnamese Americans. We will leverage PI Park’s NIA-funded Collaborative Approach for AAPI Research and Education (CARE) registry as one of our recruitment sources. Our specific aims include: 1) Establish the ARISE cohort to determine the prevalence of life course experiences of multi-level discrimination among older Chinese-, Korean-, and Vietnamese Americans; 2) Evaluate the association of multi-level discrimination on cognitive performance and levels of AD biomarkers, overall and by ASA subgroup, sex, and primary language among ARISE participants. Secondary/exploratory Aim: Evaluate the association between multi-level discrimination and cognitive decline; and 3) Evaluate protective and risk factors that modify the effects of multi-level discrimination on cognitive performance and levels of AD biomarkers among ARISE participants. The scientific promise of ARISE is timely and necessary. The COVID-19 pandemic has exposed and exacerbated anti-Asian racism. ARISE will add to our limited understanding of ASAs who are under-represented and under-engaged in ADRD and aging research.