Asian Americans & Racism: Individual and Structural Experiences (ARISE)

项目摘要/摘要 “没有问题”、“永久外国人”、“沉默的少数群体”、“都一样”--这些都是刻板印象， 长期以来一直困扰着亚裔美国人(Asa)，他们通常被称为“模范少数族裔”。就像， 然而，包含了不同的文化，语言，移民经历， 社会经济地位(SES)和宗教。对美国律师协会的种族主义和歧视不是 新的但在新冠肺炎大流行期间以新的强度重新浮出水面。个人和地区层面 种族主义和歧视与显著的健康差距有关，这影响了患上 阿尔茨海默病和相关痴呆(ADRD)。对于美国律师协会，种族主义和歧视在 个人和地区层面(例如，住宅隔离；红线)可能会导致潜在的 认知健康差异；然而，在ASA中这一领域的研究还不够深入。有限 研究表明，至少有一些ASA群体的ADRD风险低于非西班牙裔 白人个体。确定潜在的保护性因素(例如，家庭凝聚力) 减轻与种族主义有关的风险是一个重要的科学机会。研究考察了细胞因子的作用 与反兴奋剂机构对ADRD风险有关的多层次歧视是迫切需要的，但也是有限的。我们的 拟议的研究，亚裔美国人和种族主义：个人和结构性经验(RISE)， 在NIA健康差距框架的指导下，将制定一个多地点、多语言的队列 加州将研究多层次歧视的流行率和影响 在1,500名中国老年人(≥65岁)中关于ADRD相关风险的复原力资源， 韩国人和越南裔美国人。我们将利用Pi Park的NIA资助的Collaborative AAPI研究和教育(CARE)注册的方法作为我们的招聘来源之一。 我们的具体目标包括：1)建立RISE队列，以确定生命的流行率 中国、韩国和中国老年人多层次歧视的课程经历 越南裔美国人；2)多层次歧视对认知的影响 AD生物标志物的表现和水平，总体上以及按ASA亚组、性别和主要年龄分组 与会者之间的语言交流。次要/探索性目标：评估协会 多层次歧视和认知衰退之间的关系；3)评估保护性和风险性 影响多水平歧视对认知成绩和水平影响的因素 阿尔茨海默病患者的AD生物标记物。RISE的科学承诺是及时和 这是必要的。新冠肺炎大流行暴露并加剧了反亚洲种族主义。站起来 将增加我们对代表不足和参与不足的助理秘书长的有限了解 ADRD与衰老研究。

Project Summary/Abstract Problem-free”, “perpetual foreigner”, “silent minority”, “all the same” – these are stereotypes that have long plagued Asian Americans (ASAs), often referred to as the “model minority”. ASAs, however, encompasses a diversity of cultures, languages, immigration experiences, socioeconomic status (SES), and religions. Racism and discrimination against ASAs are not new but resurfaced with new intensity during the COVID-19 pandemic. Individual and area level racism and discrimination are tied to significant health disparities that influence risk of Alzheimer’s Disease and Related Dementias (ADRD). For ASAs, racism and discrimination at the individual and area level (e.g., residential segregation; redlining) may result in potential cognitive health disparities; however, this area of research in ASAs is understudied. Limited research suggests that at least some ASA groups have lower ADRD risk than non-Hispanic White individuals. Identification of potential protective factors (e.g., family cohesion) that may mitigate racism-related risk is an important scientific opportunity. Studies examining the role of multi-level discrimination related to ASAs’ risk for ADRD are sorely needed but limited. Our proposed study, Asian Americans & Racism: Individual and Structural Experiences (ARISE), guided by the NIA health disparities framework, will develop a multi-site, multi-lingual cohort in California to study the prevalence as well as the impact of multi-level discrimination and resilience resources on associated risk for ADRD among 1,500 older (≥65 years old) Chinese, Korean, and Vietnamese Americans. We will leverage PI Park’s NIA-funded Collaborative Approach for AAPI Research and Education (CARE) registry as one of our recruitment sources. Our specific aims include: 1) Establish the ARISE cohort to determine the prevalence of life course experiences of multi-level discrimination among older Chinese-, Korean-, and Vietnamese Americans; 2) Evaluate the association of multi-level discrimination on cognitive performance and levels of AD biomarkers, overall and by ASA subgroup, sex, and primary language among ARISE participants. Secondary/exploratory Aim: Evaluate the association between multi-level discrimination and cognitive decline; and 3) Evaluate protective and risk factors that modify the effects of multi-level discrimination on cognitive performance and levels of AD biomarkers among ARISE participants. The scientific promise of ARISE is timely and necessary. The COVID-19 pandemic has exposed and exacerbated anti-Asian racism. ARISE will add to our limited understanding of ASAs who are under-represented and under-engaged in ADRD and aging research.