Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

CARE 2.0项目摘要/摘要 尽管亚裔美国人是美国增长最快的种族人口， 夏威夷原住民和太平洋岛民（AANHPI）的人数仍然严重不足， research.例如，在国家阿尔茨海默氏症协调中心的参与者中， 中心数据库是AANHPI个体，参加临床试验的人更少。 有前途的治疗方法研究与教育合作方法（CARE） 登记中心（R24 AG 063718）是一个美国多语言登记中心，旨在改善AANHPI表示 阿尔茨海默病和相关痴呆症（ADRD），衰老和衰老研究。 CARE于2020年10月推出，已招募了9，405名AANHPI成人（截至10/2/22），包括 55.9%的人英语水平有限，80.9%的人以前没有参加过研究 体验. CARE已将超过5，500名参与者介绍给27项研究， 招募和研究完成阶段。作为关键的下一步，并在NIA健康 差异框架，我们建议CARE 2.0战略性地扩大登记， AANHPI参与者的招募和保留的科学，并检查因素 与转诊登记参与者的研究入组决定相关。我们的具体 目的包括：1）在10，000名新的不同队列中检查对健康研究的态度 在美国招募AANHPI成年人; 2）从CARE获得合理的观点和建议 参与者关于登记册保留的信息，并制定、实施和评估建议 注册表保留策略。采用雷电报告法进行动态监测， 定性数据分析和调查结果的快速综合，以便进行快速比较分析 跨群体和背景，以制定对不同需求敏感的有针对性的战略 保留AANHPI参与者;以及3）优化CARE登记参与者纳入NIA- 资助和其他老龄化研究，并检查因素，包括研究和参与者的水平 与参与研究有关的因素。这些创新的目标将增加和测试 CARE登记处的价值，并更广泛地告知该领域如何最好地增加 AANHPI群体在研究中的代表性。援外社完全有能力实现这些目标 并为不断发展的招聘和保留科学做出贡献。这项拟议的申请是 响应PAR-22-093（ADRD当前主题研究）和NOT-AG-21-033（通知 特别感兴趣：健康差异和AD）。

Project Summary/Abstract of CARE 2.0 Despite being the fastest growing racial population in the United States, Asian American, Native Hawaiian, and Pacific Islander (AANHPI) persons remain severely underrepresented in research. For example, less than 3% of participants in the National Alzheimer's Coordinating Center database are AANHPI individuals and even fewer are enrolled in clinical trials of promising therapeutics. The Collaborative Approach for Research and Education (CARE) registry (R24 AG063718) is a US multi-lingual registry built to improve AANHPI representation in Alzheimer’s disease and related dementias (ADRD), aging, and caregiving research. Launched in October 2020, CARE has enrolled 9,405 AANHPI adults (as of 10/2/22) including 55.9% with limited English proficiency and 80.9% with no prior research participation experience. CARE has referred more than >5,500 participants to 27 studies that are in various stages of recruitment and study completion. As a critical next step and guided by the NIA health disparities framework, we propose CARE 2.0 to strategically expand the registry, advance the science of recruitment and retention of AANHPI participants, and examine the factors associated with research enrollment decisions among referred registry participants. Our specific aims include: 1) Examine attitudes toward health research in a diverse cohort of 10,000 newly recruited AANHPI adults in the US; 2) Elicit perspectives and recommendations from CARE participants about registry retention, and develop, implement, and evaluate recommended registry retention strategies. The Lightning Report Method will be used to conduct dynamic qualitative data analysis and rapid synthesis of the findings to allow rapid comparative analyses across groups and contexts to derive targeted strategies that are sensitive to the diverse needs of retaining AANHPI participants; and 3) Optimize CARE registry participants’ inclusion in NIA- funded and other aging studies and examine factors including study- and participant-level factors associated with participation in research. These innovative aims will increase and test the value of the CARE registry and inform the field more broadly on how best to increase representation of AANHPI groups in research. CARE is well-positioned to complete these aims and contribute to the growing science of recruitment and retention. This proposed application is responsive to PAR-22-093 (Research on Current Topics in ADRD) and NOT-AG-21-033 (Notice of Special Interest: Health Disparities and AD).