Mineralocorticoid receptor co-regulator recruitment determines ligand specific signalling.

心脏病是澳大利亚和世界各地死亡和经济负担的主要原因。甾体激素醛固酮在控制水盐平衡、血压和心力衰竭中有重要作用。虽然阻断醛固酮受体的药物对心力衰竭患者有显著的帮助，但它们的使用受到副作用的限制。这项工作将确定促进醛固酮作用的蛋白质的概况，并使心脏特异性阻滞剂的开发成为可能。

Heart disease is a major cause of death and economic burden in Australia and throughout the world. The steroid hormone aldosterone controls salt and water balance,blood pressure and hasa significant role in heart failure. Although drugs that block the aldosterone receptor significantly help patients with heart failure, their use is limited by side effects. This work will identify the profile of proteins that promote aldosterone effects and enable the development of heart-specific blockers.