EAR2: a novel driver of breast cancer proliferation

阻断雌激素的药物是有效的乳腺癌治疗方法，但许多患者对其效果有抗药性。这项研究针对的是一种名为EAR2的蛋白质，与正常乳腺组织相比，乳腺癌组织中的EAR2蛋白含量较高。我们假设EAR2驱动乳腺癌细胞增殖，并将使用细胞系和小鼠模型对此进行测试。我们将验证EAR2作为一个新的治疗靶点，使目前激素治疗不足的患者受益。

Drugs that block oestrogen are effective breast cancer treatments, but many patients are resistant to their effects. This research addresses a protein known as EAR2, that is elevated in breast cancer tissue compared to normal breast. We hypothesise that EAR2 drives breast cancer cell proliferation, and will test this using cell lines and mouse models. We will validate EAR2 as a new therapeutic target, benefitting patients underserved by current hormone therapies.