EAR2: a novel driver of breast cancer proliferation

EAR2：乳腺癌增殖的新驱动因素

• 批准号: nhmrc : 1127355
• 负责人: Dr Colin Clyne
• 金额: $ 49.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ear2-novel-driver-cancer-proliferation/948001
• 关键词: EAR2; novel; driver; breast; cancer

Drugs that block oestrogen are effective breast cancer treatments, but many patients are resistant to their effects. This research addresses a protein known as EAR2, that is elevated in breast cancer tissue compared to normal breast. We hypothesise that EAR2 drives breast cancer cell proliferation, and will test this using cell lines and mouse models. We will validate EAR2 as a new therapeutic target, benefitting patients underserved by current hormone therapies.

阻断雌激素的药物是有效的乳腺癌治疗方法，但许多患者对其效果有抵抗力。这项研究涉及一种被称为EAR 2的蛋白质，与正常乳腺组织相比，该蛋白质在乳腺癌组织中升高。我们假设EAR2驱动乳腺癌细胞增殖，并将使用细胞系和小鼠模型进行测试。我们将验证EAR2作为一个新的治疗靶点，使目前激素治疗不足的患者受益。