A STUDY ON THE EFFECT OF TX ON QUALITY OF LIFE FOR MEN WITH PROSTATE CA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：这个项目将调查决策者(患者、配偶和医生)的“三位一体”，以深入了解前列腺癌的治疗决策是如何做出的。通过在治疗前对三合会进行调查，我们有机会确定做出这些决定时的影响。 研究计划：我们将从治疗前对三合会决策者的调查开始。这种方法将使我们有机会在做出决定时确定影响。在接受治疗或观察等待之后，我们将对患者和配偶进行调查，以确定在做出决定时回想起来并不相关的问题。我们将确定这些因素是否会影响生活质量和治疗满意度。我们还将评估患者的偏好、医生的建议和其他因素在多大程度上解释了男性在前列腺癌方面做出的选择中存在的相当大的种族和社会经济差异。 方法：基线调查的目标是在治疗前立即收集社会人口学信息、生活质量和合并症。我们将确定患者及其家人收到的信息来源和类型。我们将描述决策者之间的相互作用，并确定决定治疗偏好的影响因素。通过衡量所有三位决策者(患者、配偶/家庭成员和医生)的反应，我们可以调查这些个人之间的互动以及他们的个人偏好如何影响治疗决策。后续调查的目标是了解患者和家庭成员在接受治疗后偏好如何变化，并了解这些变化与特定患者的结果(包括癌症特定和全球健康相关的生活质量)之间的关系。最后的工具将利用各种经过验证的调查工具，并将通过重点小组访谈和试点测试过程提出问题。 临床相关性：这项研究将评估限制人们做出知情选择的问题。这项研究还将从其他因素中理清前列腺癌治疗选择对生活质量和护理满意度的影响。如果实现了这些短期目标，长期目标就是帮助前列腺癌患者及其配偶或伴侣做出明智的决定，反映他们的价值观和对治疗的期望。这项研究的信息将被用作未来干预研究的基础，旨在改善患有局限性前列腺癌的男性的决策、对治疗过程的满意度和生活质量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This project will survey the "triad" of decision-makers (patient, spouse, and physician) to gain insight into how prostate cancer treatment decisions are made. By surveying the triad before treatment, we have the opportunity to identify influences at the time these decisions are made. RESEARCH PLAN: We will start by surveying the triad of decision-makers before treatment. This approach will give us the opportunity to identify influences at the time of the decision. Following treatment, or watchful waiting, we will survey patients and spouse to identify issues that, in retrospect, were irrelevant at the time of the decision was being made. We will determine whether these factors influence quality of life and treatment satisfaction. We will also evaluate the degree to which patient preferences, physicians' recommendations and other factors account for the considerable racial and socioeconomic disparity in the choices men make regarding their prostate cancer. METHODS: The objective of the baseline survey is to collect sociodemographic information, quality of life and co-morbidity, immediately prior to treatment. We will identify the sources and type of information patients and their family members receive. We will characterize interactions among decision-makers and identify influential factors in determining treatment preference. By measuring responses from all three decision-makers (patient, spouse/family member and physician), we can investigate the interactions between these individuals and how their individual preferences influence the treatment decision. The goal of the follow-up survey is to understand how preferences change, following treatment for patients and family members, and understand how these changes are associated with patient-specific outcomes including cancer specific and global health-related quality of life. The final instruments will utilize a variety of validated survey instruments and will develop questions, through a process of focus group interviews and pilot testing. CLINICAL RELEVANCE: This study will assess issues that limit persons from making informed choices. This study will also disentangle the influence of prostate cancer treatment choices from other factors on QOL and satisfaction with care. If these short term objectives are achieved, the long term goals are to help prostate cancer patients and their spouse or partner make well-informed decisions reflecting their values and expectations for treatment. The information from this study will be used as the basis for future intervention studies designed to improve decision-making, satisfaction with the treatment process and quality of life for men with localized prostate cancer.