PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
基本信息
- 批准号:10227705
- 负责人:
- 金额:$ 65.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-20 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse eventAfrican AmericanAgeAge related macular degenerationAgingAlzheimer&aposs DiseaseAmerican Medical AssociationAncillary StudyAndrogen MetabolismAtrophicBiologicalBiopsyBloodCancer Research InfrastructureCardiovascular systemCataractCause of DeathCessation of lifeClinicalClinical Trials DesignCollaborationsColoradoColorectalColorectal CancerColorectal PolypControlled Clinical TrialsCountryDataData CollectionData ElementData LinkagesData SetDatabasesDiagnosisDietDiseaseDocumentationDouble-Blind MethodDouble-blind trialEtiologyFinasterideFundingGenotypeGrantIncidenceInflammationInfrastructureInstitutionInsulin ResistanceJournalsLeukocytesLife StyleMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of prostateMeasuresMedical HistoryMedicareMedicineMinorityNational Clinical Trials NetworkNew EnglandParticipantPathologyPharmaceutical PreparationsPhasePhysical activityPlacebosPlasmaProceduresPrognosisProgram Research Project GrantsProstateProstate Cancer Prevention TrialProstate-Specific AntigenPublicationsPublishingQuality of lifeRandomizedRandomized Clinical TrialsReportingResearch DesignResearch PersonnelRespiratory physiologyRiskRisk FactorsSamplingScheduleScreening for Prostate CancerSecureSeleniumSelenium and Vitamin E Efficacy TrialSerumSouthwest Oncology GroupSpecimenStructure of nail of toeTissue BanksTissue SampleTissuesUnited StatesUniversitiesUpdateVisitVitamin EWashingtonanticancer researcharmbiobankcancer diagnosiscancer epidemiologyclinical databasecohortdata dictionarydata repositorydata sharingdietary supplementsdigitalepidemiology studyfollow-upgenetic associationgenome wide association studygenome-wideindexinglower urinary tract symptomsmalemembermenoxidative damageplacebo controlled studyplacebo groupprospectiveprostate biopsyprostate cancer riskrandomized trialrectalrepositorysecondary endpointstatistical centeruser-friendly
项目摘要
PROJECT SUMMARY/ABSTRACT
The SWOG Statistical Center in Seattle, Washington, served as the coordinating center for two large prostate
cancer prevention trials: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate
Cancer Prevention Trial (PCPT). SELECT was a Phase III, double-blind, placebo-controlled study designed to
assess the effect of selenium and vitamin E, alone and in combination, primarily on prostate cancer incidence
and secondarily on other cancer incidence. SELECT randomized 35,533 men between 2001 and 2004. PCPT,
also a Phase III, double-blind trial, randomized 18,882 men to either finasteride or placebo between 1994 and
1997. Although schedules and requirements varied between the two studies, substantial serum, plasma, white
blood cells, and prostate tissue were collected on both, resulting in rich biorepositories.
Each had extensive prospective data collections which included diet and dietary supplements, quality of life,
physical activity, medications, other cancer diagnoses, cardiovascular endpoints, and treatment adverse events.
Although there have been significant scientific collaborations to date, there remain numerous opportunities to
further interrogate the clinical database and biobanks. Additionally, serum and plasma measures and extensive
genotyping data have already been obtained and are available for other investigators to use.
These cohorts are fully mature with 6,045 deaths and median follow-up of 18.4 years on PCPT and 3,762 deaths
and median follow-up of 10.1 years on SELECT. There have been 2,401 and 2,475 prostate cancers detected
during the trials plus an additional 890 and 338 prostate cancers identified via Medicare linkage in PCPT and
SELECT, respectively. Other primary cancers have also been documented either during the trials or through
data linkage. In addition to being able to extend the results of these well-conducted, randomized clinical trials
through linkages to Medicare, NDI and completed GWAS studies, these data can be used for epidemiologic
research as part of the ongoing consortium projects.
We request funds to continue to enrich the cohorts by collecting new data elements such as end point data from
Medicare and National Death Index linkages. We plan to update our linkages early in the upcoming grant period.
We also request support for the cohort team to develop detailed documentation and data sets to load into the
Cancer Epidemiology Data Repository, and we ask for continued support to provide a stable infrastructure for
the PCPT serum and PCPT and SELECT tissue repositories (all located at the University of Colorado). With
continued funding for the Statistical Center and some of our key scientific colleagues, we will be able to provide
administrative assistance and expertise to investigators who apply for additional funding to conduct studies using
our rich biologic repositories and clinical databases from PCPT and SELECT.
项目总结/摘要
位于华盛顿西雅图的SWOG统计中心作为两个大型前列腺增生症的协调中心,
癌症预防试验:硒和维生素E癌症预防试验(SELECT)和前列腺
癌症预防试验(PCPT)。SELECT是一项III期、双盲、安慰剂对照研究,
评估硒和维生素E单独或联合使用对前列腺癌发病率的影响
其次是其他癌症的发病率。SELECT在2001年至2004年期间随机分配了35,533名男性。PCPT,
这也是一项III期双盲试验,在1994年至2005年期间,将18,882名男性随机分为非那肽组或安慰剂组。
1997.尽管两项研究的时间表和要求不同,但大量血清、血浆、白色
血细胞和前列腺组织被收集在两者上,产生丰富的生物储存库。
每个人都有广泛的前瞻性数据收集,包括饮食和膳食补充剂,生活质量,
体力活动、药物治疗、其他癌症诊断、心血管终点和治疗不良事件。
虽然迄今为止已经有了重要的科学合作,但仍然有许多机会,
进一步查询临床数据库和生物库。此外,血清和血浆测量和广泛的
基因分型数据已经获得,可供其他研究人员使用。
这些队列完全成熟,有6,045例死亡,PCPT的中位随访时间为18.4年,有3,762例死亡
中位随访时间为10.1年。分别检测出2,401例和2,475例前列腺癌
在试验期间,通过PCPT中的医疗保险联系确定了另外890和338例前列腺癌,
分别选择。其他原发性癌症也在试验期间或通过
数据连接除了能够扩展这些进行良好的随机临床试验的结果之外
通过与医疗保险、NDI和已完成的GWAS研究的联系,这些数据可用于流行病学研究。
研究作为正在进行的财团项目的一部分。
我们要求拨款,继续通过收集新的数据元素,如终点数据,
医疗保险和国家死亡指数的联系。我们计划在即将到来的赠款期间尽早更新我们的联系。
我们还请求支持队列团队开发详细的文档和数据集,以加载到
癌症流行病学数据库,我们要求继续提供支持,为以下方面提供稳定的基础设施:
PCPT血清以及PCPT和SELECT组织储存库(均位于科罗拉多大学)。与
继续资助统计中心和我们的一些关键科学同事,我们将能够提供
为申请额外资金以使用
我们丰富的生物资源库和临床数据库来自PCPT和SELECT。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
IAN M. THOMPSON其他文献
IAN M. THOMPSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('IAN M. THOMPSON', 18)}}的其他基金
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
10460634 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
Enhancing the PCPT/SELECT cohorts Core Infrastructure Grant to support studies evaluating dietary supplement use and disease risk
加强 PCPT/SELECT 队列核心基础设施拨款,以支持评估膳食补充剂使用和疾病风险的研究
- 批准号:
9413226 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
8634305 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
10601377 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
10670915 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
8738631 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research
PCPT 和 SELECT 队列:癌症研究的核心基础设施支持
- 批准号:
9339971 - 财政年份:2013
- 资助金额:
$ 65.32万 - 项目类别:
Improving prostate biopsy efficiency: The finasteride challenge test
提高前列腺活检效率:非那雄胺激发试验
- 批准号:
8137196 - 财政年份:2010
- 资助金额:
$ 65.32万 - 项目类别:
Improving prostate biopsy efficiency: The finasteride challenge test
提高前列腺活检效率:非那雄胺激发试验
- 批准号:
7987292 - 财政年份:2010
- 资助金额:
$ 65.32万 - 项目类别:
相似海外基金
Planar culture of gastrointestinal stem cells for screening pharmaceuticals for adverse event risk
胃肠道干细胞平面培养用于筛选药物不良事件风险
- 批准号:
10707830 - 财政年份:2023
- 资助金额:
$ 65.32万 - 项目类别:
Hospital characteristics and Adverse event Rate Measurements (HARM) Evaluated over 21 years.
医院特征和不良事件发生率测量 (HARM) 经过 21 年的评估。
- 批准号:
479728 - 财政年份:2023
- 资助金额:
$ 65.32万 - 项目类别:
Operating Grants
Analysis of ECOG-ACRIN adverse event data to optimize strategies for the longitudinal assessment of tolerability in the context of evolving cancer treatment paradigms (EVOLV)
分析 ECOG-ACRIN 不良事件数据,以优化在不断发展的癌症治疗范式 (EVOLV) 背景下纵向耐受性评估的策略
- 批准号:
10884567 - 财政年份:2023
- 资助金额:
$ 65.32万 - 项目类别:
AE2Vec: Medical concept embedding and time-series analysis for automated adverse event detection
AE2Vec:用于自动不良事件检测的医学概念嵌入和时间序列分析
- 批准号:
10751964 - 财政年份:2023
- 资助金额:
$ 65.32万 - 项目类别:
Understanding the real-world adverse event risks of novel biosimilar drugs
了解新型生物仿制药的现实不良事件风险
- 批准号:
486321 - 财政年份:2022
- 资助金额:
$ 65.32万 - 项目类别:
Studentship Programs
Pediatric Adverse Event Risk Reduction for High Risk Medications in Children and Adolescents: Improving Pediatric Patient Safety in Dental Practices
降低儿童和青少年高风险药物的儿科不良事件风险:提高牙科诊所中儿科患者的安全
- 批准号:
10676786 - 财政年份:2022
- 资助金额:
$ 65.32万 - 项目类别:
Pediatric Adverse Event Risk Reduction for High Risk Medications in Children and Adolescents: Improving Pediatric Patient Safety in Dental Practices
降低儿童和青少年高风险药物的儿科不良事件风险:提高牙科诊所中儿科患者的安全
- 批准号:
10440970 - 财政年份:2022
- 资助金额:
$ 65.32万 - 项目类别:
Improving Adverse Event Reporting on Cooperative Oncology Group Trials
改进肿瘤学合作组试验的不良事件报告
- 批准号:
10642998 - 财政年份:2022
- 资助金额:
$ 65.32万 - 项目类别:
Planar culture of gastrointestinal stem cells for screening pharmaceuticals for adverse event risk
胃肠道干细胞平面培养用于筛选药物不良事件风险
- 批准号:
10482465 - 财政年份:2022
- 资助金额:
$ 65.32万 - 项目类别:
Expanding and Scaling Two-way Texting to Reduce Unnecessary Follow-Up and Improve Adverse Event Identification Among Voluntary Medical Male Circumcision Clients in the Republic of South Africa
扩大和扩大双向短信,以减少南非共和国自愿医疗男性包皮环切术客户中不必要的后续行动并改善不良事件识别
- 批准号:
10191053 - 财政年份:2020
- 资助金额:
$ 65.32万 - 项目类别: