Mass Spectrometry

质谱

• 批准号: 8934643
• 负责人: IAN M. THOMPSON
• 金额: $ 7.39万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8934643
• 关键词: Award; Cancer Center; Consultations; Core Facility; Development; Disease; Doctor of Philosophy; Funding; Health Sciences; Location; Malignant Neoplasms; Mass Spectrum Analysis; Mission; Modification; NCI Center for Cancer Research; Neoplasm Metastasis; Peer Review; Peptides; Process; Proteins; Proteomics; Publications; Research Personnel; Resource Sharing; Services; South Texas; Texas; Therapeutic Agents; Therapeutic Studies; Training; Universities; cancer therapy; mass spectrometry shared resource; member; metabolomics; molecular mass; operation; protein metabolite; research facility; research study; small molecule

The mission of the Mass Spectrometry Shared Resource (MSSR) is to provide Cancer Therapy & Research Center (CTRC) members and University of Texas Health Science Center (UTHSCSA) investigators with comprehensive, state-of-the-art support for characterization and quantification of proteins, metabolites and other biomedically important molecules using mass spectrometry. The MSSR has been in operation since 1979 and became a Cancer Center Shared Resource in 1998. There are two components of the MSSR, proteomics and metabolomics, which operate at two locations, a 713 sq. ft. space (Proteomics) on the Long (main) campus of the UTHSCSA and a 782 sq. ft. space (Metabolomics) on the Greehey (north) campus of the UTHSCSA in the South Texas Research Facility (STRF). The MSSR is jointly managed by the University and the CTRC. The MSSR services include molecular mass determination, protein identification, protein quantification, sequence characterization of peptides, localization covalent modification, and metabolomics (discovery experiments, targeted quantitative analysis, and small molecule analysis by GC-MS). The shared resource also offers consultations and training to CTRC investigators. The MSSR is directed by Susan Weintraub, Ph.D. The staff of the MSSR includes two-technical Directors, Kevin W. Hakala, M.S, (Proteomics) and Xiaoli Gao, Ph.D., (Metabolomics) with Sam Pardo as the Core Facilities Technologist. The MSSR team has expertise in the use of mass spectrometry to solve important cancer-related questions. During the last award year, the MSSR serviced 14 peer-review funded cancer center members, which comprised 19% of the total core users and contributed to 29 cancer-related peer-reviewed publications during the last funding period. Usage for the first half of 2013 increased two-fold, likely due to the addition of Metabolomics as a service.

质谱共享资源（MSSR）的使命是为癌症治疗与研究中心（CTRC）成员和德克萨斯大学健康科学中心（UTHSCSA）的研究人员提供全面的、最先进的支持，使用质谱技术对蛋白质、代谢物和其他生物医学上重要的分子进行表征和定量。MSSR自1979年开始运作，并于1998年成为癌症中心共享资源。MSSR有两个组成部分，蛋白质组学和代谢组学，它们在713平方英尺的两个位置工作。在UTHSCSA的长（主）校园和782平方英尺的空间（蛋白质组学）。在南德克萨斯研究设施（STRF）的UTHSCSA的格里希（北）校区（代谢组学）。中心由学校和中心共同管理。MSSR服务包括分子质量测定、蛋白质鉴定、蛋白质定量、肽序列表征、定位共价修饰和代谢组学（发现实验、靶向定量分析和GC-MS小分子分析）。共享资源还为CTRC调查人员提供咨询和培训。MSSR由Susan Weintraub博士领导。MSSR的工作人员包括两名技术主任，Kevin W. Hakala硕士（蛋白质组学）和Xiaoli Gao博士（代谢组学），Sam Pardo为核心设施技术专家。MSSR团队在使用质谱法解决重要的癌症相关问题方面具有专业知识。在上一个奖励年度，MSSR为14个同行评审资助的癌症中心成员提供服务，占核心用户总数的19%，并在上一个资助期间贡献了29份与癌症相关的同行评审出版物。2013年上半年的使用量增长了两倍，可能是由于增加了代谢组学服务。