PRENATAL PASSIVE EXPOSURE AND PREGNANCY OUTCOMES

产前被动暴露和妊娠结局

• 批准号: 7607360
• 负责人: KRISTIN ASHFORD
• 金额: $ 8.72万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607360
• 关键词: Adverse effects; Biological Markers; Birth; Computer Retrieval of Information on Scientific Projects Database; Control Locus; Data; Exposure to; Funding; Gestational Age; Grant; Hair; Health; Home environment; Infant; Infant Health; Institution; Intervention; Knowledge; Measurement; Measures; Methods; Mothers; Newborn Infant; Nicotine; Outcome; Participant; Passive Smoking; Patient Self-Report; Policies; Population; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Purpose; Recruitment Activity; Research; Research Personnel; Resources; Sampling; Science; Smoke; Smoking; Smoking History; Smoking Status; Source; United States National Institutes of Health; Urine; day; depressive symptoms; design; fetal; prenatal; prenatal exposure; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the relationship between level of prenatal passive smoke exposure and birth outcomes using hair nicotine analysis. The long-term objective of this research is to develop effective interventions to reduce prenatal exposure to passive smoke. With increased knowledge regarding the adverse health effects of passive smoke on fetal and infant health, mothers may take additional precautions to avoid exposure during pregnancy. A correlational, cross-sectional, non-experimental study using a quota sampling design will be used. A multiethnic population of 200 pregnant women will be recruited to participate. Data will be collected on self-reported secondhand smoke (SHS) exposure, smoking history, home smoking policy, depressive symptoms, fetal health locus of control (FHLC), nicotine levels in maternal and infant hair and birth outcomes. Birth outcome data includes: birthweight, gestational age, method of delivery, delivery complications, and immediate newborn complications. All data will be collected during the immediate postpartum period (1-4 days following delivery). Participants will be asked to provide a hair sample for nicotine measurement of prenatal SHS exposure and a urine sample to validate smoking status. Newborn hair samples will also be collected and matched to their mother's sample. This research is critical for advancing the science of biomarker usage for measuring prenatal SHS smoke exposure, in order to correctly identify and quantify adverse effects of exposure on birth outcome.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是通过头发尼古丁分析来检查产前被动烟雾暴露水平与出生结果之间的关系。这项研究的长期目标是制定有效的干预措施，以减少产前被动吸烟的暴露。随着人们越来越了解被动吸烟对胎儿和婴儿健康的不利影响，母亲可以采取额外的预防措施来避免在怀孕期间接触二手烟。将使用采用配额抽样设计的相关、横断面、非实验研究。将招募 200 名多民族孕妇参加。将收集有关自我报告的二手烟（SHS）暴露、吸烟史、家庭吸烟政策、抑郁症状、胎儿健康控制点（FHLC）、母婴头发中的尼古丁水平以及出生结果的数据。出生结果数据包括：出生体重、胎龄、分娩方式、分娩并发症和新生儿即刻并发症。所有数据将在产后期间（分娩后 1-4 天）收集。参与者将被要求提供头发样本以测量产前二手烟暴露的尼古丁含量，并提供尿液样本以验证吸烟状况。新生儿的头发样本也将被收集并与母亲的样本进行匹配。这项研究对于推进测量产前二手烟暴露的生物标记物使用科学至关重要，以便正确识别和量化暴露对出生结果的不利影响。